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Biological Data Biological description Potent JAK inhibitor. Inhibits JAK3, JAK2 and JAK1 (IC50 values are 1, 20 and 112 nM respectively). Reduces pro-inflammatory cytokine release. Shows immunosuppressant actions.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (3R ,4R )-4-Methyl-3-(methyl-7H -pyrro lo[2,3-d ]pyrimidin-4-ylamino)-β-oxo-1-piperidinepro panenitrile citrate
Chemical structure
Molecular Formula C16 H20 N6 O.C6 H8 O7
PubChem identifier 10174505
SMILES C[C@H]1[C@@H](N(C2=NC=NC3=C2C=CN3)C)CN(C(CC#N)=O)CC1.OC(CC(O)=O)(C(O)=O)CC(O)=O
InChiKey SYIKUFDOYJFGBQ-YLAFAASESA-N
References for CP 690550 citrate (Tofacitinib citrate) References are publications that support the biological activity of the product
CP-690550 Treatment Ameliorates Established Disease and Provides Long-Term Therapeutic Effects in an SKG Arthritis Model. Oh K et al (2013) Immune Netw 13(6) : 257-63. Discovery of CP-690,550: a potent and selective Janus kinase (JAK) inhibitor for the treatment of autoimmune diseases and organ transplant rejection. Flanagan ME et al (2010) J Med Chem 53(24) : 8468-84. Examining the chirality, conformation and selective kinase inhibition of 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile (CP-690,550). Jiang JK et al (2008) J Med Chem 51(24) : 8012-8.
![CP 690550 citrate [540737-29-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1427.png "CP 690550 citrate [540737-29-9]")
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