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Biological Data Biological description STAT3 inhibitor (IC50 = 4.6 µM). Also inhibits human acetylcholinesterase (AChE), butyrylcholinesterase (BuChE) and SHP2 (IC50 values are 4.09, 6.38 and 22.5 µM respectively). Shows anti-Alzheimer's disease, anticancer, antidiabetic and antiobesity actions.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 1,2,6,7,8,9-Hexahydro-1,6,6-trimethyl[1,2-b ]furan-10,11-dione
Chemical structure
Molecular Formula C19 H20 O3
PubChem identifier 160254
SMILES O=C(C1=C(C4=C3[C@@H](C)CO4)C=CC2=C1CCCC(C)2C)C3=O
InChiKey GVKKJJOMQCNPGB-JTQLQIEISA-N
References for Cryptotanshinone References are publications that support the biological activity of the product
Inhibitory effect of cryptotanshinone on angiogenesis and Wnt/β-catenin signaling pathway in human umbilical vein endothelial cells. Chen Q et al (2014) Chin J Integr Med 20(10) : 743-50. Cryptotanshinone, an acetylcholinesterase inhibitor from Salvia miltiorrhiza, ameliorates scopolamine-induced amnesia in Morris water maze task. Wong KK et al (2010) Planta Med 76(3) : 228-34. Cryptotanshinone inhibits constitutive signal transducer and activator of transcription 3 function through blocking the dimerization in DU145 prostate cancer cells. Shin DS et al (2009) Cancer Res 69(1) : 193-202. Antidiabetes and antiobesity effect of cryptotanshinone via activation of AMP-activated protein kinase. Kim EJ et al (2007) Mol Pharmacol 72(1) : 62-72.
![Cryptotanshinone [35825-57-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1434.png "Cryptotanshinone [35825-57-1]")
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