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Biological Data
| Biological description | Serine protease inhibitor. Orally active.
Show various biological actions including antiviral, anticancer and suppresses pancreatitis-induced pain in rats.
Inhibits the transmembrane protease TMPRSS2 and partially blocks entry of SARS-Cov-2 into lung cells in vitro. |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100mM) and in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate |
| Chemical structure | ![Camostat mesylate [59721-29-8] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Camostat mesylate [59721-29-8]") |
| Molecular Formula | C20H22N4O5.CH3SO3H |
| SMILES | O=C(C2=CC=C(NC(N)=N)C=C2)OC1=CC=C(CC(OCC(N(C)C)=O)=O)C=C1.CS(=O)(O)=O |
| InChi | InChI=1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4) |
| InChiKey | FSEKIHNIDBATFG-UHFFFAOYSA-N |
References for Camostat mesylate
References are publications that support the biological activity of the product
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SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Hoffmann et al (2020) Cell. 181(2) : 271-380 -
Camostat mesilate inhibits prostasin activity and reduces blood pressure and renal injury in salt-sensitive hypertension
Maekawa et al (2009) J Hypertens. 27(1) : 181-9 -
The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodent
Ishikura et al (2007) Life Sci. 80(21) : 1999-2004
Serine protease inhibitor. Inhibits TMPRSS2 and partially blocks SARS-Cov2 entry in vitro.
![Camostat mesylate [59721-29-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3595_1.png "Camostat mesylate [59721-29-8]")
Understanding purity and quality - a guide for life scientists
