Target

Antimalarial. Apoptosis and autophagy inhibitor.

Selective mGlu₄ agonist

Mitochondrial permeability transition pore (MPTP) activator

Water soluble prototypic, atypical antipsychotic. Binds to both serotonin and dopamine receptors.

Dihydrochloride salt of CNO - the prototypical DREADD activator

mGlu_1α / mGlu_5a agonist

Potent, selective and metabolically stable hM3Dq and hM4Di muscarinic DREADD actuator.

Selective group I mGlu receptor agonist. Induces LTD.

Selective ERβ estrogen receptor agonist

Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator. Brain penetrant. Water soluble.