Product overview
| Name | Cinnabarinic acid |
| Description | Selective mGlu4 agonist |
| Purity | >98% |
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Biological Data
| Biological description | Selective mGlu4 receptor agonist. Endogenous metabolite of the kynurenine pathway. Shows no activity at other mGlu receptors. Protective against EAE, a multiple sclerosis model in mice. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid |
| Molecular Weight | 300.22 |
| Chemical structure | ![Cinnabarinic acid [606-59-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0195.png "Cinnabarinic acid [606-59-7]") |
| Molecular Formula | C14H8N2O6 |
| CAS Number | 606-59-7 |
| PubChem identifier | 114918 |
| SMILES | O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2 |
| InChiKey | FSBKJYLVDRVPTK-UHFFFAOYSA-N |
References for Cinnabarinic acid
References are publications that support the biological activity of the product
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Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.
Fazio F et al (2014) Neuropharmacology 81 : 237-43. -
An expanding range of targets for kynurenine metabolites of tryptophan.
Stone TW et al (2013) Trends Pharmacol Sci 34(2) : 136-43. -
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.
Fazio F et al (2012) Mol Pharmacol 81(5) : 643-56.
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