Product overview

Name Cinnabarinic acid
Description Selective mGlu4 agonist
Purity >98%
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Biological Data

Biological description Selective mGlu4 receptor agonist. Endogenous metabolite of the kynurenine pathway. Shows no activity at other mGlu receptors. Protective against EAE, a multiple sclerosis model in mice.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid
Molecular Weight 300.22
Chemical structure Cinnabarinic acid  [606-59-7] Chemical Structure
Molecular Formula C14H8N2O6
CAS Number 606-59-7
PubChem identifier 114918
SMILES O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2
InChiKey FSBKJYLVDRVPTK-UHFFFAOYSA-N

References for Cinnabarinic acid

References are publications that support the biological activity of the product
  • Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.

    Fazio F et al (2014) Neuropharmacology 81 : 237-43.
  • An expanding range of targets for kynurenine metabolites of tryptophan.

    Stone TW et al (2013) Trends Pharmacol Sci 34(2) : 136-43.
  • Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.

    Fazio F et al (2012) Mol Pharmacol 81(5) : 643-56.