Product overview
Name | Cinnabarinic acid |
Description | Selective mGlu4 agonist |
Purity | >98% |
Write Your Own Review
Biological Data
Biological description | Selective mGlu4 receptor agonist. Endogenous metabolite of the kynurenine pathway. Shows no activity at other mGlu receptors. Protective against EAE, a multiple sclerosis model in mice. |
Solubility & Handling
Storage instructions | -20°C |
Solubility overview | Soluble in DMSO (100mM) |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | 2-Amino-3-oxo-3H-phenoxazine-1,9-dicarboxylic acid |
Molecular Weight | 300.22 |
Chemical structure | |
Molecular Formula | C14H8N2O6 |
CAS Number | 606-59-7 |
PubChem identifier | 114918 |
SMILES | O=C2C(N)=C(C(O)=O)C1=NC3=C(C=CC=C3C(O)=O)OC1=C2 |
InChiKey | FSBKJYLVDRVPTK-UHFFFAOYSA-N |
References for Cinnabarinic acid
References are publications that support the biological activity of the product
-
Cinnabarinic acid, an endogenous agonist of type-4 metabotropic glutamate receptor, suppresses experimental autoimmune encephalomyelitis in mice.
Fazio F et al (2014) Neuropharmacology 81 : 237-43. -
An expanding range of targets for kynurenine metabolites of tryptophan.
Stone TW et al (2013) Trends Pharmacol Sci 34(2) : 136-43. -
Cinnabarinic acid, an endogenous metabolite of the kynurenine pathway, activates type 4 metabotropic glutamate receptors.
Fazio F et al (2012) Mol Pharmacol 81(5) : 643-56.