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Biological Data Biological description mGlu1α and mGlu5a receptor agonist in RGT cell lines. Also acts as a NMDA receptor agonist and PLD-coupled mGlu receptor agonist.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical structure
Molecular Formula C3 H7 NO4 S.H2 O
PubChem identifier 1549098
SMILES [H][C@](N)(CS(O)=O)C(O)=O
InChiKey ADVPTQAUNPRNPO-REOHCLBHSA-N
References for L-Cysteinesulfinic acid monohydrate References are publications that support the biological activity of the product
Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway. Servitja JM et al (2003) Neuropharmacology 44(2) : 171-80. Sulphur-containing amino acids are agonists for group 1 metabotropic receptors expressed in clonal RGT cell lines. Kingston AE et al (1998) Neuropharmacology 37(3) : 277-87. L-cysteine sulfinic acid as an endogenous agonist of a novel metabotropic receptor coupled to stimulation of phospholipase D activity. Boss V et al (1994) Mol Pharmacol 45(6) : 1177-82. Sulphur-containing excitatory amino acid-stimulated inositol phosphate formation in primary cultures of cerebellar granule cells is mediated predominantly by N-methyl-D-aspartate receptors. Gorman A et al (1994) Neuroscience 59(2) : 299-308.
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