Cytokines, chemokines & NF-κB/I-κB
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Cytokines and chemokines play an important role in the modulation of inflammation and acts as key modulators of inflammation by acting through a variety of complex pathways and interactions.
Proinflammatory cytokines activate the IKK complex and closely interact with NF-κB and JAK/STAT signaling.
- Description:
Water soluble Toll-like receptor 7 (TLR7) agonist. Stimulates cytokine production.
Purity:>98%
Ionomycin calcium salt (HB1001)
Description:Calcium ionophore. Stimulates cytokine production.
Purity:>98%
Ionomycin free acid (HB1002)
Description:Calcium ionophore. Stimulates cytokine production.
Purity:>98%
LIH383 (HB9242)
Description:Potent and selective ACKR3 (CXCR7) agonist. Potentiates opioid peptide activity.
- Description:
Novel, intracellular covalent chemokine CCR2 negative allosteric modulator (NAM). Binds irreversibly.
Monensin sodium salt (HB4882)
Description:Protein transport inhibitor. Commonly used in cytokine staining.
Purity:>98%
- Description:
PKC activator. Widely used for THP-1 cell differentiation and with ionomycin for stimulating cytokine production
Purity:>99%
SP600125 (HB2234)
Description:Selective, ATP-competitive JNK inhibitor. Prevents BMP9-induced osteogenic MSC differentiation. Maintains stem cells in naive pluripotent state.
Purity:>98%