Phorbol 12-myristate 13-acetate (PMA) is a protein kinase C (PKC) activator which associates to the C1 domain. It is structurally analogous to diacylglycerol and has various biological actions. It induces ERK1/2 activation.
It is widely used to differentiate THP-1 cells for use as a model for function and biology of human macrophages.
It is frequently used with ionomycin to stimulate intracellular cytokine production in T-cells. Also used with Concanavalin A (ConA) to stimulate DNA and protein synthesis.
PMA also facilitates long term potentiation in hippocampal neurons via δ and ε PKC binding sites.
Additionally, PMA potentiates exocytosis and modulates vesicle fusion kinetics.
It is a potent tumor promoter.
Solubility & Handling
-20°C (protect from light)
Soluble in DMSO (100mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.