Ionomycin free acid

(HB1002)
Technical documents: SDS CoA Datasheet

Product overview

Name Ionomycin free acid
Description Calcium ionophore. Stimulates cytokine production.
Purity >98%
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Biological Data

Biological description

Potent calcium ionophore which shows selectivity for Ca2+ over Mg2+ and K+. Acts as a Ca2+ carrier. Ionomycin calcium salt also available.

Directly stimulates store-regulated cation entry across biological membranes to enhance Ca2+ influx and increase intracellular Ca2+ concentration.

Synergies with with phorbol myristate acetate (PMA) to enhance activation of PKC. Frequently used in combination with PMA to stimulate T-cell activation and intracellular production of cytokines.

Also induces apoptosis.

Calcium ionophore A23187 also available.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in ethanol (10 mM) and DMSO (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
Molecular Weight 709.01
Molecular Formula C41H72O9
CAS Number 56092-81-0
PubChem identifier 6912226
SMILES C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\O
InChiKey PGHMRUGBZOYCAA-ADZNBVRBSA-N
MDL number MFCD06798385
Appearance White to off-white

References for Ionomycin free acid

References are publications that support the biological activity of the product
  • PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells.

    Han S et al (2013) PLoS One 8(10) : e76717.
  • Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.

    Kauffman RF et al (1980) J Biol Chem 255(7) : 2735-9.
  • Characterization of ionomycin as a calcium ionophore.

    Liu C et al (1978) J Biol Chem 253(17) : 5892-4.