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Biological Data Biological description Potent calcium ionophore which shows selectivity for Ca2+ over Mg2+ and K+ . Acts as a Ca2+ carrier. Ionomycin calcium salt also available.
Directly stimulates store-regulated cation entry across biological membranes to enhance Ca2+ influx and increase intracellular Ca2+ concentration.
Synergies with with phorbol myristate acetate (PMA) to enhance activation of PKC. Frequently used in combination with PMA to stimulate T-cell activation and intracellular production of cytokines.
Also induces apoptosis.
Calcium ionophore A23187 also available.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in ethanol (10 mM) and DMSO (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid
Molecular Formula C41 H72 O9
PubChem identifier 6912226
SMILES C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\O
InChiKey PGHMRUGBZOYCAA-ADZNBVRBSA-N
Appearance White to off-white
References for Ionomycin free acid References are publications that support the biological activity of the product
PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells. Han S et al (2013) PLoS One 8(10) : e76717. Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria. Kauffman RF et al (1980) J Biol Chem 255(7) : 2735-9. Characterization of ionomycin as a calcium ionophore. Liu C et al (1978) J Biol Chem 253(17) : 5892-4.
Calcium ionophore. Stimulates cytokine production.
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