Ionomycin free acid
(HB1002)
Product overview
| Name | Ionomycin free acid |
| Description | Calcium ionophore. Stimulates cytokine production. |
| Purity | >98% |
Write Your Own Review
Biological Data
| Biological description | Potent calcium ionophore which shows selectivity for Ca2+ over Mg2+ and K+. Acts as a Ca2+ carrier. Ionomycin calcium salt also available. Directly stimulates store-regulated cation entry across biological membranes to enhance Ca2+ influx and increase intracellular Ca2+ concentration. Synergies with with phorbol myristate acetate (PMA) to enhance activation of PKC. Frequently used in combination with PMA to stimulate T-cell activation and intracellular production of cytokines. Also induces apoptosis. Calcium ionophore A23187 also available. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in ethanol (10 mM) and DMSO (10 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid |
| Molecular Weight | 709.01 |
| Molecular Formula | C41H72O9 |
| CAS Number | 56092-81-0 |
| PubChem identifier | 6912226 |
| SMILES | C[C@H](CCC(=O)O)C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\O |
| InChiKey | PGHMRUGBZOYCAA-ADZNBVRBSA-N |
| MDL number | MFCD06798385 |
| Appearance | White to off-white |
References for Ionomycin free acid
References are publications that support the biological activity of the product
-
PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells.
Han S et al (2013) PLoS One 8(10) : e76717. -
Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.
Kauffman RF et al (1980) J Biol Chem 255(7) : 2735-9. -
Characterization of ionomycin as a calcium ionophore.
Liu C et al (1978) J Biol Chem 253(17) : 5892-4.
Technical guides
Understanding purity and quality - a guide for life scientistsRelated Products
