Ionomycin calcium salt

(HB1001)
Technical documents: SDS CoA Datasheet

Product overview

Name Ionomycin calcium salt
Description Calcium ionophore. Stimulates cytokine production.
Purity >98%
Customer comments

Ionomycin calcium salt does what it should. This was my first time buying a product from Hello Bio. I am pleased with their customer service and follow up. The product was delivered in a relatively short time as estimated. The product dose causes the intracellular calcium to be released as expected. Overall experience with Hello Bio was good. Verified customer, UEA: University of East Anglia)

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Biological Data

Biological description

Ionomycin calcium salt is a potent calcium ionophore which shows selectivity for Ca2+ over Mg2+ and K+. It acts as a Ca2+ carrier and is the calcium salt of ionomycin.


Ionomycin directly stimulates store-regulated cation entry across biological membranes to enhance Ca2+ influx and increase intracellular Ca2+ concentration.


Ionomycin also synergies with phorbol myristate acetate (PMA) to enhance activation of PKC and is frequently used in combination with PMA to stimulate T-cell activation and intracellular production of cytokines.

Ionomycin also induces apoptosis.


Calcium ionophore A23187 also available.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in ethanol (100 mM) and DMSO (25 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt
Molecular Weight 747.08
Molecular Formula C41H70CaO9
CAS Number 56092-82-1
PubChem identifier 6446270
SMILES C[C@H](CCC(=O)[O-])C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\[O-].[Ca+2]
InChi InChI=1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-2
InChiKey WKRWUYKLUMMAKG-WYGBAUISSA-L
MDL number MFCD00083634
Appearance White to off-white

References for Ionomycin calcium salt

References are publications that support the biological activity of the product
  • PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells.

    Han S et al (2013) PLoS One 8(10) : e76717.
  • Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.

    Kauffman RF et al (1980) J Biol Chem 255(7) : 2735-9.
  • Characterization of ionomycin as a calcium ionophore.

    Liu C et al (1978) J Biol Chem 253(17) : 5892-4.