Ionomycin calcium salt
Product overview
| Name | Ionomycin calcium salt |
| Description | Calcium ionophore. Stimulates cytokine production. |
| Purity | >98% |
| Customer comments | Ionomycin calcium salt does what it should. This was my first time buying a product from Hello Bio. I am pleased with their customer service and follow up. The product was delivered in a relatively short time as estimated. The product dose causes the intracellular calcium to be released as expected. Overall experience with Hello Bio was good. Verified customer, UEA: University of East Anglia) |
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Biological Data
| Biological description | Ionomycin calcium salt is a potent calcium ionophore which shows selectivity for Ca2+ over Mg2+ and K+. It acts as a Ca2+ carrier and is the calcium salt of ionomycin.
Ionomycin also induces apoptosis.
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Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in ethanol (100 mM) and DMSO (25 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | (4R,6S,8S,10Z,12R,14R,16E,18R,19R,20S,21S)-11,19,21-Trihydroxy-4,6,8,12,14,18,20-heptamethyl-22-[(2S,2'R,5S,5'S)-octahydro-5'-[(1R)-1-hydroxyethyl]-2,5'-dimethyl[2,2'-bifuran]-5-yl]-9-oxo-10,16-docosadienoic acid calcium salt |
| Molecular Weight | 747.08 |
| Molecular Formula | C41H70CaO9 |
| CAS Number | 56092-82-1 |
| PubChem identifier | 6446270 |
| SMILES | C[C@H](CCC(=O)[O-])C[C@H](C)C[C@H](C)C(=O)/C=C(/[C@H](C)C[C@H](C)C/C=C/[C@@H](C)[C@H]([C@@H](C)[C@H](C[C@@H]1CC[C@@](O1)(C)[C@H]2CC[C@@](O2)(C)[C@@H](C)O)O)O)\[O-].[Ca+2] |
| InChi | InChI=1S/C41H72O9.Ca/c1-25(21-29(5)34(43)24-35(44)30(6)22-27(3)20-26(2)14-15-38(46)47)12-11-13-28(4)39(48)31(7)36(45)23-33-16-18-41(10,49-33)37-17-19-40(9,50-37)32(8)42;/h11,13,24-33,36-37,39,42-43,45,48H,12,14-23H2,1-10H3,(H,46,47);/q;+2/p-2/b13-11+,34-2 |
| InChiKey | WKRWUYKLUMMAKG-WYGBAUISSA-L |
| MDL number | MFCD00083634 |
| Appearance | White to off-white |
References for Ionomycin calcium salt
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PMA and ionomycin induce glioblastoma cell death: activation-induced cell-death-like phenomena occur in glioma cells.
Han S et al (2013) PLoS One 8(10) : e76717. -
Cation transport and specificity of ionomycin. Comparison with ionophore A23187 in rat liver mitochondria.
Kauffman RF et al (1980) J Biol Chem 255(7) : 2735-9. -
Characterization of ionomycin as a calcium ionophore.
Liu C et al (1978) J Biol Chem 253(17) : 5892-4.
Understanding purity and quality - a guide for life scientists
