ROCK (Rho-kinase)

Potent, selective PKA inhibitor

Potent, selective mTOR inhibitor

Endogenous ionotropic glutamate / nicotinic antagonist.

Na²⁺ / K⁺ / Ca²⁺ channel inhibitor. Anticonvulsant.

Actin polymerization inhibitor

Potent and selective ACKR3 (CXCR7) agonist. Potentiates opioid peptide activity.

Novel, potent covalent A_2A antagonist. Binds irreversibly.

Novel, covalent Affinity-Based Probe (AfBP). Clickable antagonist for the A₂AR.

Novel, intracellular covalent chemokine CCR2 negative allosteric modulator (NAM). Binds irreversibly.

Novel, potent, selective A₃AR covalent antagonist