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Purmorphamine

(HB3412)
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Product overview

Name Purmorphamine
Alternative names Shh Signaling Antagonist VI
Purity >98%
Description

Smo receptor agonist that activates the hedgehog pathway. Induces mesenchymal and iPSC differentiation.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (4) Frequently bought together
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Biological Data

Biological description

Smo receptor agonist that activates the Hedgehog (Hh) signaling pathway to induce osteogenesis in multipotent mesenchymal progenitor cells. Also promotes differentiation of pre-adipocytes and myoblasts into osteoblasts when use in combination with BMP-4.

Frequently used to differentiate pluripotent stem cells (e.g. ESCs and iPSCs) to neural stem cells and defined neuronal populations such as motor neurons and midbrain dopaminergic neurons. Protocols often use puromorphamine in combination with CHIR99021 (CHIR), SB431542 (SB), LDN193189 (LDN), XAV939, Y-27632, DAPT, BDNF, GDNF, retinoic acid (RA) and forskolin).

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 9-Cyclohexyl-N-[4-(4-morpholinyl)ph enyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Molecular Weight 520.62
Chemical structure Purmorphamine | [483367-10-8] Chemical Structure
Molecular Formula C31H32N6O2
CAS Number 483367-10-8
PubChem identifier 5284329
SMILES C1(OC4=CC=CC5=C4C=CC=C5)=NC(NC3=CC=C(N6CCOCC6)C=C3)=C2C(N(C7CCCCC7)C=N2)=N1
InChi InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
InChiKey FYBHCRQFSFYWPY-UHFFFAOYSA-N
MDL number MFCD28988971

References for Purmorphamine

References are publications that support the biological activity of the product

  • Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.

    El-Akabawy G et al (2011) Stem cells and development 20 : 1873-87
    Read more (PubMedID: 21345011)

  • Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs.

    Hu BY et al (2010) Methods in molecular biology (Clifton, N.J.) 636 : 123-37
    Read more (PubMedID: 20336520)

  • Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

    Sinha S et al (2006) Nature chemical biology 2 : 29-30
    Read more (PubMedID: 16408088)

  • Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.

    Wu X et al (2004) Chemistry & biology 11 : 1229-38
    Read more (PubMedID: 15380183)

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Order: HB3412
Pack PriceQty
5mg
$99
10mg
$171
25mg
$386

Smo receptor agonist that activates the hedgehog pathway. Induces mesenchymal and iPSC differentiation.

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