Smo receptor agonist that activates the Hedgehog (Hh) signaling pathway to induce osteogenesis in multipotent mesenchymal progenitor cells. Also promotes differentiation of pre-adipocytes and myoblasts into osteoblasts when use in combination with BMP-4.
Frequently used to differentiate pluripotent stem cells (e.g. ESCs and iPSCs) to neural stem cells and defined neuronal populations such as motor neurons and midbrain dopaminergic neurons. Protocols often use puromorphamine in combination with CHIR99021 (CHIR), SB431542 (SB), LDN193189 (LDN), XAV939, Y-27632, DAPT, BDNF, GDNF, retinoic acid (RA) and forskolin).
Solubility & Handling
Soluble in DMSO (100mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.