Product overview

Name Purmorphamine
Alternative names Shh Signaling Antagonist VI
Purity >98%

Smo receptor agonist that activates the hedgehog pathway. Induces mesenchymal and iPSC differentiation.

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Biological Data

Biological description

Smo receptor agonist that activates the Hedgehog (Hh) signaling pathway to induce osteogenesis in multipotent mesenchymal progenitor cells. Also promotes differentiation of pre-adipocytes and myoblasts into osteoblasts when use in combination with BMP-4.

Frequently used to differentiate pluripotent stem cells (e.g. ESCs and iPSCs) to neural stem cells and defined neuronal populations such as motor neurons and midbrain dopaminergic neurons. Protocols often use puromorphamine in combination with CHIR99021 (CHIR), SB431542 (SB), LDN193189 (LDN), XAV939, Y-27632, DAPT, BDNF, GDNF, retinoic acid (RA) and forskolin).

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 9-Cyclohexyl-N-[4-(4-morpholinyl)ph enyl]-2-(1-naphthalenyloxy)-9H-purin-6-amine
Molecular Weight 520.62
Chemical structure Purmorphamine |  [483367-10-8] Chemical Structure
Molecular Formula C31H32N6O2
CAS Number 483367-10-8
PubChem identifier 5284329
InChi InChI=1S/C31H32N6O2/c1-2-9-25(10-3-1)37-21-32-28-29(33-23-13-15-24(16-14-23)36-17-19-38-20-18-36)34-31(35-30(28)37)39-27-12-6-8-22-7-4-5-11-26(22)27/h4-8,11-16,21,25H,1-3,9-10,17-20H2,(H,33,34,35)
MDL number MFCD28988971

References for Purmorphamine

References are publications that support the biological activity of the product
  • Purmorphamine increases DARPP-32 differentiation in human striatal neural stem cells through the Hedgehog pathway.

    El-Akabawy G et al (2011) Stem cells and development 20 : 1873-87
  • Directed differentiation of neural-stem cells and subtype-specific neurons from hESCs.

    Hu BY et al (2010) Methods in molecular biology (Clifton, N.J.) 636 : 123-37
  • Purmorphamine activates the Hedgehog pathway by targeting Smoothened.

    Sinha S et al (2006) Nature chemical biology 2 : 29-30
  • Purmorphamine induces osteogenesis by activation of the hedgehog signaling pathway.

    Wu X et al (2004) Chemistry & biology 11 : 1229-38

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