Nuclear Receptors
Nuclear hormone receptors (nuclear receptors) are specialised transcription factors which bind to specific sequences of DNA of particular target genes. They regulate transcription of these target genes in response to a variety of endogenous ligands. Nuclear receptors are classified into two major subfamilies: steroid and non-steroid hormone receptors. Steroid hormone receptors include receptors for estrogen (ER), androgen, glucocorticoid, mineralocorticoid and progesterone. Examples of non-steroid hormone receptors include thyroid receptors, retinoic acid receptors and peroxisome proliferator-activated receptors (PPAR). Researchers can save up to 50% on nuclear hormone receptor agonists, antagonists and modulators from Hello Bio - they are up to half the price of other suppliers.
Pifithrin-α hydrobromide (HB2478)
Description:p53 inhibitor and Aryl hydrocarbon receptor agonist. Supresses ESC self renewal.
Purity:>98%
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Pioglitazone hydrochloride (HB2554)
Description:Selective PPARγ agonist. Enhances mESCs proliferation and survival.
Purity:>99%
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Purmorphamine (HB3412)
Description:Smo receptor agonist that activates the hedgehog pathway. Induces mesenchymal and iPSC differentiation.
Purity:>98%
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Rosiglitazone (HB2556)
Description:Potent and selective PPARγ agonist. Promotes adipocyte differentiation and enhances NPC proliferation.
Purity:>99%
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SAG (HB3107)
Description:Cell permeable Sonic hedgehog (Shh) agonist and Smo agonist. Enhances neuronal differentiation of iPSC into dopaminergic neurons.
Purity:>98%
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Strontium chloride (HB3424)
Description:Calcium sensing receptor (CaSR) agonist. Induces MSC osteogenic differentiation.
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Troglitazone (HB2559)
Description:Potent, selective PPARγ agonist. Inhibits hematopoietic cell line growth.
Purity:>97%
