Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
MPEP hydrochloride (HB0426)
Description:Potent, selective mGluR5 antagonist / mGluR4 positive allosteric modulator
Purity:>98%
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MRS 2179 ammonium salt (HB4241)
Description:Selective P2Y1 antagonist. Inhibits platelet aggregation.
Purity:>98%
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MTEP hydrochloride (HB0431)
Description:Potent, highly selective, non-competitive mGluR5 antagonist
Purity:>98%
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Naspm trihydrochloride (HB0441)
Description:Selective GluA2- lacking, Ca2+ permeable AMPA / kainate receptor antagonist
Purity:>95%
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NBQX disodium salt (HB0443)
Description:Potent, selective, competitive AMPA receptor antagonist. Disodium salt.
Purity:>99%
