MTEP hydrochloride

(HB0431)
Technical documents: SDS CoA Datasheet

Product overview

Name MTEP hydrochloride
Description Potent, highly selective, non-competitive mGluR5 antagonist
Purity >98%
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MTEP hydrochloride vial

Biological Data

Biological description

MTEP hydrochloride is a potent, highly selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM and Ki = 16 nM in an in vitro Ca2+-flux assay).


MTEP has no significant effect on other mGluRs and shows fewer off-target effects than MPEP hydrochlorideMTEP shows ~10-fold greater selectivity for mGlu5 than MPEP.


MTEP also blocks induction of tLTP (timing-dependent long term potentiation) and has antidepressant, anxiolytic and neuroprotective properties.


MTEP is active in vivo.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 3-((2-Methyl-1,3-thiazol-4-yl)ethynyl)pyridine hydrochloride
Molecular Weight 236.72
Chemical structure MTEP hydrochloride  [1186195-60-7] Chemical Structure
Molecular Formula C11H8N2S.HCl
CAS Number 1186195-60-7
PubChem identifier 45073467
SMILES CC1=NC(=CS1)C#CC2=CN=CC=C2.Cl
Source Synthetic
InChi InChI=1S/C11H8N2S.ClH/c1-9-13-11(8-14-9)5-4-10-3-2-6-12-7-10;/h2-3,6-8H,1H3;1H
InChiKey YCIOJDKGCWAHLR-UHFFFAOYSA-N
MDL number MFCD08458895
Appearance Light cream solid

References for MTEP hydrochloride

References are publications that support the biological activity of the product
  • Gating of NMDA receptor-mediated hippocampal spike timing-dependent potentiation by mGluR5.

    Kwag and Paulsen (2012) Neuropharmacology 63(4) : 701-9
  • Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation.

    Keck TM et al (2012) ACS Med Chem Lett 3(7) : 544-549.
  • NMDA but not AMPA glutamatergic receptors are involved in the antidepressant-like activity of MTEP during the forced swim test in mice.

    Pomierny-Chamioło L et al (2010) Pharmacol Rep 62(6) : 1186-90.
  • Neuroprotective potential of mGluR5 antagonist MTEP: effects on kainate-induced excitotoxicity in the rat hippocampus.

    Domin H et al (2010) Pharmacol Rep 62(6) : 1051-61.
  • Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP.

    Lea and Faden (2006) CNS Drug Rev. 12(2) : 149-66
Publications
These publications cite the use of MTEP hydrochloride purchased from Hello Bio:
  • Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

    Kallergi et al. (2020) bioRxiv preprint : 1-46
  • The role of glutamate mGlu5 and adenosine A2a receptor interactions in regulating working memory performance and persistent cocaine seeking in rats

    Hamor et al (2020) Prog Neuropsychopharmacol Biol Psychiatry : doi: 10.1016/j.pnpbp.2020.109979
    PubMedID: 32470496
  • An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety.

    Ramos-Prats et al (2019) Front Mol Neurosci. 19 : 12:30
    PubMedID: 30873001

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