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Biological Data Biological description Competitive P2Y1 antagonist (Ki = 100 nM) which shows selectivity over P2Y2 , P2Y4 ,P2Y6 and P2X1 , P2X3 , P2X2 , P2X4 receptors. Strongly inhibits ADP-induced platelet aggregation in vitro and ex vivo and shows antithrombotic action.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name 2'-Deoxy-N 6 -methyladenosine 3',5'-bisphosphate ammonium salt
Chemical structure
Molecular Formula C11 H17 N5 O9 P2 .4NH3
PubChem identifier 5311303
SMILES CNC1=C2C(=NC=N1)N(C=N2)[C@H]3C[C@@H]([C@H](O3)COP(=O)(O)O)OP(=O)(O)O
InChi InChI=1S/C11H17N5O9P2/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(25-27(20,21)22)7(24-8)3-23-26(17,18)19/h4-8H,2-3H2,1H3,(H,12,13,14)(H2,17,18,19)(H2,20,21,22)/t6-,7+,8+/m0/s1
InChiKey CCPLITQNIFLYQB-XLPZGREQSA-N
References for MRS 2179 ammonium salt References are publications that support the biological activity of the product
Anti-inflammatory effect of P2Y1 receptor blocker MRS2179 in a rat model of traumatic brain injury. Kumagawa T et al (2022) Brain research bulletin 181 : 46-54 The ADP antagonist MRS2179 regulates the phenotype of smooth muscle cells to limit intimal hyperplasia. Liu R et al (2015) Cardiovascular drugs and therapy 29 : 23-9 The P2Y(1) receptor as a target for new antithrombotic drugs: a review of the P2Y(1) antagonist MRS-2179. Baurand A et al (2003) Cardiovascular drug reviews 21 : 67-76 Inhibition of platelet function by administration of MRS2179, a P2Y1 receptor antagonist. Baurand A et al (2001) European journal of pharmacology 412 : 213-21
Publications
These publications cite the use of MRS 2179 ammonium salt purchased from Hello Bio:
Genetically Encoded Biosensors Unveil Neuronal Injury Dynamics via Multichromatic ATP and Calcium Imaging. Ghaffari Zaki A et al (2024) ACS sensors 9 : 1261-1271
Selective P2Y1 antagonist. Inhibits platelet aggregation.
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