Naloxone hydrochloride

Name: Naloxone hydrochloride
Brand: Hello Bio
SKU: HB2451
Price: 57 USD
Availability: InStock

(HB2451)

Publications (4)

Technical documents: SDS CoA Datasheet

Product overview

Name

Naloxone hydrochloride

Alternative names

NLX

Purity

>99%

Description

Competitive opioid receptor antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Publications (4) References (3) Frequently bought together

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Biological Data

Biological description

Competitive opioid receptor antagonist with high affinity at µ-opioid receptors. Blocks effects of opiods. Induces acute withdrawal state in opiate-dependent models.

Active in vivo.

Solubility & Handling

Storage instructions

Room temperature

Solubility overview

Soluble in water (100 mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

(5α)-4,5-Epoxy-3,14-dihydro-17-(2-pr openyl)morphinan-6-one hydrochloride

Molecular Weight

363.84

Chemical structure

Molecular Formula

C₁₉H₂₁NO₄.HCl

CAS Number

357-08-4

PubChem identifier

5464092

SMILES

C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl

InChi

InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1

InChiKey

RGPDIGOSVORSAK-STHHAXOLSA-N

MDL number

MFCD00150901

Appearance

White solid

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Naloxone hydrochloride

References are publications that support the biological activity of the product

Error correction in latent inhibition and its disruption by opioid receptor blockade with naloxone.
Leung et al (2013) Neuropsychopharmacology 38(12) : 2439-45
Read more (PubMedID: 23748224)
Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.
Spivak et al (1997) Mol Pharmacol 52(6) : 983-92
Read more (PubMedID: 9415708)
Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.
Pinelli et al (1997) J Pharmacol Toxicol Methods 38(3) : 117-31
Read more (PubMedID: 9523765)

Publications

Submit Yours Now

These publications cite the use of Naloxone hydrochloride purchased from Hello Bio:

Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons
Farrens et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441175 : doi
Voltage modulates the effect of μ receptor activation in a ligand-dependent manner
Ruland et al. (2020) Br J Pharmacol. : 1
PubMedID: 32297669
A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase
Groom et al (2020) British Journal of Pharmacology - : doi:10.1111/bph.15334
PubMedID: 33245558
Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry
Arttamangkul S et al (2019) Elife 8
PubMedID: 31589142

Competitive opioid receptor antagonist

Order: HB2451
Pack	Price	Qty
100mg	$57

Naloxone hydrochloride

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Naloxone hydrochloride

Error correction in latent inhibition and its disruption by opioid receptor blockade with naloxone.

Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.

Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.

Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons

Voltage modulates the effect of μ receptor activation in a ligand-dependent manner

A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

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Tell us about your publication!

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Naloxone hydrochloride

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Naloxone hydrochloride

Error correction in latent inhibition and its disruption by opioid receptor blockade with naloxone.

Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.

Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.

Functional independence of endogenous μ-and δ-opioid receptors co-expressed in cholinergic interneurons

Voltage modulates the effect of μ receptor activation in a ligand-dependent manner

A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

Visualizing endogenous opioid receptors in living neurons using ligand-directed chemistry

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Tell us about your publication!

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