Product overview

Name Naloxone hydrochloride
Description Competitive opioid receptor antagonist
Alternative names NLX
Purity >99%
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Biological Data

Biological description

Competitive opioid receptor antagonist with high affinity at µ-opioid receptors. Blocks effects of opiods. Induces acute withdrawal state in opiate-dependent models.

Active in vivo.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (5α)-4,5-Epoxy-3,14-dihydro-17-(2-pr openyl)morphinan-6-one hydrochloride
Molecular Weight 363.84
Chemical structure Naloxone hydrochloride Chemical Structure
Molecular Formula C19H21NO4.HCl
CAS Number 357-08-4
PubChem identifier 5464092
SMILES C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl
InChi InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1
InChiKey RGPDIGOSVORSAK-STHHAXOLSA-N
MDL number MFCD00150901
Appearance White solid

References for Naloxone hydrochloride

References are publications that support the biological activity of the product
  • Error correction in latent inhibition and its disruption by opioid receptor blockade with naloxone.

    Leung et al (2013) Neuropsychopharmacology 38(12) : 2439-45
  • Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.

    Spivak et al (1997) Mol Pharmacol 52(6) : 983-92
  • Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.

    Pinelli et al (1997) J Pharmacol Toxicol Methods 38(3) : 117-31
Publications
These publications cite the use of Naloxone hydrochloride purchased from Hello Bio:
  • Voltage modulates the effect of μ receptor activation in a ligand-dependent manner

    Ruland et al. (2020) Br J Pharmacol. : 1
    PubMedID: 32297669
  • A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase

    Groom et al (2020) British Journal of Pharmacology - : doi:10.1111/bph.15334
    PubMedID: 33245558

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