Product overview
| Name | Naloxone hydrochloride |
| Description | Competitive opioid receptor antagonist |
| Alternative names | NLX |
| Purity | >99% |
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Biological Data
| Biological description | Competitive opioid receptor antagonist with high affinity at µ-opioid receptors. Blocks effects of opiods. Induces acute withdrawal state in opiate-dependent models. Active in vivo. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (5α)-4,5-Epoxy-3,14-dihydro-17-(2-pr openyl)morphinan-6-one hydrochloride |
| Molecular Weight | 363.84 |
| Chemical structure |  |
| Molecular Formula | C19H21NO4.HCl |
| CAS Number | 357-08-4 |
| PubChem identifier | 5464092 |
| SMILES | C=CCN1CC[C@]23[C@@H]4C(=O)CC[C@]2([C@H]1CC5=C3C(=C(C=C5)O)O4)O.Cl |
| InChi | InChI=1S/C19H21NO4.ClH/c1-2-8-20-9-7-18-15-11-3-4-12(21)16(15)24-17(18)13(22)5-6-19(18,23)14(20)10-11;/h2-4,14,17,21,23H,1,5-10H2;1H/t14-,17+,18+,19-;/m1./s1 |
| InChiKey | RGPDIGOSVORSAK-STHHAXOLSA-N |
| MDL number | MFCD00150901 |
| Appearance | White solid |
References for Naloxone hydrochloride
References are publications that support the biological activity of the product
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Error correction in latent inhibition and its disruption by opioid receptor blockade with naloxone.
Leung et al (2013) Neuropsychopharmacology 38(12) : 2439-45 -
Naloxone activation of mu-opioid receptors mutated at a histidine residue lining the opioid binding cavity.
Spivak et al (1997) Mol Pharmacol 52(6) : 983-92 -
Quantitative evaluation of opioid withdrawal signs in rats repeatedly treated with morphine and injected with naloxone, in the absence or presence of the antiabstinence agent clonidine.
Pinelli et al (1997) J Pharmacol Toxicol Methods 38(3) : 117-31
Publications
These publications cite the use of Naloxone hydrochloride purchased from Hello Bio:
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Voltage modulates the effect of μ receptor activation in a ligand-dependent manner
Ruland et al. (2020) Br J Pharmacol. : 1PubMedID: 32297669 -
A novel G protein‐biased agonist at the μ opioid receptor induces substantial receptor desensitisation through G protein‐coupled receptor kinase
Groom et al (2020) British Journal of Pharmacology - : doi:10.1111/bph.15334PubMedID: 33245558
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