Naspm trihydrochloride

Technical documents: SDS CoA Datasheet

Product overview

Name Naspm trihydrochloride
Description Selective GluA2- lacking, Ca2+ permeable AMPA / kainate receptor antagonist
Purity >95%
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Biological Data

Biological description Selective GluA2- lacking, Ca2+ permeable AMPA/kainate receptor antagonist. Synthetic analogue of Joro spider toxin. Reduces excitatory post synaptic currents in infralimbic neurons.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
Molecular Weight 479.91
Chemical structure Naspm trihydrochloride  [1049731-36-3] Chemical Structure
Molecular Formula C22H34N4O.3HCl
CAS Number 1049731-36-3
PubChem identifier 16219727
InChi InChI=1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
MDL number MFCD01321052

References for Naspm trihydrochloride

References are publications that support the biological activity of the product
  • ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.

    Park K et al (2014) PLoS One 9(6) : e100108.
  • Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.

    Sepulveda-Orengo MT et al (2013) J Neurosci 33(17) : 7184-93.
  • Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.

    Koike M et al (1997) Neurosci Res 29(1) : 27-36.
These publications cite the use of Naspm trihydrochloride purchased from Hello Bio:
  • Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons

    Joffe ME et al (2022) Neuron 110(6) : 1068-1083.e5
    PubMedID: 35045338
  • Intracellular NASPM allows an unambiguous functional measure of GluA2-lacking calcium-permeable AMPA receptor prevalence

    Coombs et al (2021) bioRxiv : doi
  • Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice

    Miao HH et al (2021) Mol Brain 14(1) : 140
    PubMedID: 34526080
  • Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens

    Skiteva O et al (2021) Transl Psychiatry 11(1) : 530
    PubMedID: 34650029
  • Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula

    Nuno-Perez et al (2021) Neuron. 109(6) : 947-956
    PubMedID: 33535028

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