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Images
Naspm trihydrochloride product vial image | Hello Bio
Naspm trihydrochloride product vial image | Hello Bio
Biological Data
| Biological description | Selective GluA2- lacking, Ca2+ permeable AMPA/kainate receptor antagonist. Synthetic analogue of Joro spider toxin. Reduces excitatory post synaptic currents in infralimbic neurons. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride |
| Chemical structure | ![Naspm trihydrochloride [1049731-36-3] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Naspm trihydrochloride [1049731-36-3]") |
| Molecular Formula | C22H34N4O.3HCl |
| PubChem identifier | 16219727 |
| SMILES | C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN.Cl.Cl.Cl |
| InChi | InChI=1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H |
| InChiKey | JNEOJAUJWOPWJS-UHFFFAOYSA-N |
References for Naspm trihydrochloride
References are publications that support the biological activity of the product
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ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.
Park K et al (2014) PLoS One 9(6) : e100108. -
Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.
Sepulveda-Orengo MT et al (2013) J Neurosci 33(17) : 7184-93. -
Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.
Koike M et al (1997) Neurosci Res 29(1) : 27-36.
Publications
These publications cite the use of Naspm trihydrochloride purchased from Hello Bio:
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Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons
Joffe ME et al (2022) Neuron 110(6) : 1068-1083.e5 -
Intracellular NASPM allows an unambiguous functional measure of GluA2-lacking calcium-permeable AMPA receptor prevalence
Coombs et al (2021) bioRxiv https://doi.org/10.1101/2021.02.18.431828 : doi -
Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice
Miao HH et al (2021) Mol Brain 14(1) : 140 -
Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens
Skiteva O et al (2021) Transl Psychiatry 11(1) : 530 -
Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula
Nuno-Perez et al (2021) Neuron. 109(6) : 947-956
Selective GluA2- lacking, Ca2+ permeable AMPA / kainate receptor antagonist
![Naspm trihydrochloride [1049731-36-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0441.png "Naspm trihydrochloride [1049731-36-3]")
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