Naspm trihydrochloride

(HB0441)
Technical documents: SDS CoA Datasheet

Product overview

Name Naspm trihydrochloride
Description Selective GluA2- lacking, Ca2+ permeable AMPA / kainate receptor antagonist
Purity >95%
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Biological Data

Biological description Selective GluA2- lacking, Ca2+ permeable AMPA/kainate receptor antagonist. Synthetic analogue of Joro spider toxin. Reduces excitatory post synaptic currents in infralimbic neurons.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name N-[3-[[4-[(3-Aminopropyl)amino]butyl]amino]propyl]-1-naphthaleneacetamide trihydrochloride
Molecular Weight 479.91
Chemical structure Naspm trihydrochloride  [1049731-36-3] Chemical Structure
Molecular Formula C22H34N4O.3HCl
CAS Number 1049731-36-3
PubChem identifier 16219727
SMILES C1=CC=C2C(=C1)C=CC=C2CC(=O)NCCCNCCCCNCCCN.Cl.Cl.Cl
InChi InChI=1S/C22H34N4O.3ClH/c23-12-6-15-24-13-3-4-14-25-16-7-17-26-22(27)18-20-10-5-9-19-8-1-2-11-21(19)20;;;/h1-2,5,8-11,24-25H,3-4,6-7,12-18,23H2,(H,26,27);3*1H
InChiKey JNEOJAUJWOPWJS-UHFFFAOYSA-N
MDL number MFCD01321052

References for Naspm trihydrochloride

References are publications that support the biological activity of the product
  • ABA renewal involves enhancements in both GluA2-lacking AMPA receptor activity and GluA1 phosphorylation in the lateral amygdala.

    Park K et al (2014) PLoS One 9(6) : e100108.
  • Fear extinction induces mGluR5-mediated synaptic and intrinsic plasticity in infralimbic neurons.

    Sepulveda-Orengo MT et al (2013) J Neurosci 33(17) : 7184-93.
  • Blocking effect of 1-naphthyl acetyl spermine on Ca(2+)-permeable AMPA receptors in cultured rat hippocampal neurons.

    Koike M et al (1997) Neurosci Res 29(1) : 27-36.
Publications
These publications cite the use of Naspm trihydrochloride purchased from Hello Bio:
  • Acute restraint stress redirects prefrontal cortex circuit function through mGlu5 receptor plasticity on somatostatin-expressing interneurons

    Joffe ME et al (2022) Neuron 110(6) : 1068-1083.e5
    PubMedID: 35045338
  • Intracellular NASPM allows an unambiguous functional measure of GluA2-lacking calcium-permeable AMPA receptor prevalence

    Coombs et al (2021) bioRxiv https://doi.org/10.1101/2021.02.18.431828 : doi
  • Brain-derived neurotrophic factor produced long-term synaptic enhancement in the anterior cingulate cortex of adult mice

    Miao HH et al (2021) Mol Brain 14(1) : 140
    PubMedID: 34526080
  • Ketamine induces opposite changes in AMPA receptor calcium permeability in the ventral tegmental area and nucleus accumbens

    Skiteva O et al (2021) Transl Psychiatry 11(1) : 530
    PubMedID: 34650029
  • Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula

    Nuno-Perez et al (2021) Neuron. 109(6) : 947-956
    PubMedID: 33535028

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