Naltrexone hydrochloride

(HB2452)
Technical documents: SDS Datasheet

Product overview

Name Naltrexone hydrochloride
Alternative names NTX
Purity >99%
Description Competitive opioid receptor antagonist
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Biological Data

Biological description Competitive opioid receptor antagonist (Ki values are 1.55, 7.84 and 0.71 nM at µ, δ and κ receptors respectively). Diminishes alcohol reward and motivation and decreases alcohol drinking. Active in vivo.

Solubility & Handling

Solubility overview Soluble in water (100 mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name (5α)-17-(Cyclopropylmethyl)-4,5-epox y-3,14-dihydromorphinan-6-one hydrochloride
Molecular Weight 377.87
Chemical structure Naltrexone hydrochloride Chemical Structure
Molecular Formula C20H23NO4.HCl
CAS Number 16676-29-2
PubChem identifier 5485201
SMILES C1CC1CN2CC[C@]34[C@@H]5C(=O)CC[C@]3([C@H]2CC6=C4C(=C(C=C6)O)O5)O.Cl
InChi InChI=1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1
InChiKey RHBRMCOKKKZVRY-ITLPAZOVSA-N
MDL number MFCD00069324
Appearance White solid
Publications
These publications cite the use of Naltrexone hydrochloride purchased from Hello Bio:
  • Synaptic regulation by OPRM1 variants in reward neurocircuitry.

    Popova et al (2019) J Neurosci : 2317-18
    PubMedID: 31109961

1 Item