Product overview

Name MPEP hydrochloride
Description Potent, selective mGluR5 antagonist / mGluR4 positive allosteric modulator
Purity >98%
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MPEP hydrochloride: Scientist Approved

Biological Data

Biological description

MPEP hydrochloride is a potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 36 nM) and also a mGlu4 receptor positive allosteric modulator (PAM).


MPEP prevents induction of various types of long term potentiation (LTP) and long term depression (LTD).

MPEP also suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. MPEP is blood-brain barrier (BBB) permeable and is active in vivo.


Water soluble MTEP hydrochloride is also available.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100mM) and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 2-Methyl-6-(phenylethynyl)pyridine hydrochloride
Molecular Weight 229.71
Chemical structure MPEP hydrochloride  [219911-35-0] Chemical Structure
Molecular Formula C14H11N.HCl
CAS Number 219911-35-0
PubChem identifier 9794588
SMILES CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl
Source Synthetic
InChi InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChiKey PKDHDJBNEKXCBI-UHFFFAOYSA-N
MDL number MFCD02262119
Appearance White solid

References for MPEP hydrochloride

References are publications that support the biological activity of the product
  • Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.

    Latif-Hernandez et al (2016) Front Cell Neurosci. 7; : 10:252
  • Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.

    Mihov and Hasler (2016) Int J Neuropsychopharmacol. 5; : 19(7)
  • NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.

    Izumi and Zorumski (2012) Neuropsychopharmacology 37(3) : 609-17
  • 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.

    Gasparini F et al (1999) Neuropharmacology 38(10) : 1493-503.
Publications
These publications cite the use of MPEP hydrochloride purchased from Hello Bio:
  • Mechanisms Underlying Long-Term Synaptic Zinc Plasticity at Mouse Dorsal Cochlear Nucleus Glutamatergic Synapses

    Vogler NW et al (2020) J Neurosci 40(26) : 4981-4996
    PubMedID: 32434779
  • Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses

    Tzounopoulos and Vogler (2018) bioRxiv doi : https://doi.org/10.1101/320671
  • Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors

    Bellini et al (2017) bioRxiv : https://doi.org/10.1101/224477
  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580
  • Exploring the Role for mGluR5 in Regulating Striatal Medium Spiny Neuron Development

    Bhagat, S. (2016) Duke Dissertations : 1-102

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