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Images MPEP hydrochloride: Scientist Approved
MPEP hydrochloride product vial image | Hello Bio
MPEP hydrochloride: Scientist Approved MPEP hydrochloride product vial image | Hello Bio Biological Data Biological description MPEP hydrochloride is a potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 36 nM) and also a mGlu4 receptor positive allosteric modulator (PAM).
MPEP also suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. MPEP is blood-brain barrier (BBB) permeable and is active in vivo .
MTEP hydrochloride is also available.
Solubility & Handling Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO (100mM) and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 2-Methyl-6-(phenylethynyl)pyridine hydrochloride
Chemical structure
Molecular Formula C14 H11 N.HCl
PubChem identifier 9794588
SMILES CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl
InChi InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
InChiKey PKDHDJBNEKXCBI-UHFFFAOYSA-N
References for MPEP hydrochloride References are publications that support the biological activity of the product
Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs. Latif-Hernandez et al (2016) Front Cell Neurosci. 7; : 10:252 Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window. Mihov and Hasler (2016) Int J Neuropsychopharmacol. 5; : 19(7) NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression. Izumi and Zorumski (2012) Neuropsychopharmacology 37(3) : 609-17 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. Gasparini F et al (1999) Neuropharmacology 38(10) : 1493-503.
Publications
These publications cite the use of MPEP hydrochloride purchased from Hello Bio:
Voltage tunes mGlu5 receptor function, impacting synaptic transmission Perroy et al (2023) bioRxiv https://www.biorxiv.org/content/10.1101/2023.07.17.549279v1.abstract
Mechanisms Underlying Long-Term Synaptic Zinc Plasticity at Mouse Dorsal Cochlear Nucleus Glutamatergic Synapses Vogler NW et al (2020) J Neurosci 40(26) : 4981-4996 Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses Tzounopoulos and Vogler (2018) bioRxiv doi : https://doi.org/10.1101/320671
Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors Bellini et al (2017) bioRxiv : https://doi.org/10.1101/224477
PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology. Sweeny et al (2017) Sci Rep. 7 : 43606
Potent, selective mGluR5 antagonist / mGluR4 positive allosteric modulator
![MPEP hydrochloride [219911-35-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0426.png "MPEP hydrochloride [219911-35-0]")
Understanding purity and quality - a guide for life scientists
