Product overview
| Name | MPEP hydrochloride |
| Description | Potent, selective mGluR5 antagonist / mGluR4 positive allosteric modulator |
| Purity | >98% |
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Biological Data
| Biological description | MPEP hydrochloride is a potent, selective and non-competitive mGlu5 receptor antagonist (IC50 = 36 nM) and also a mGlu4 receptor positive allosteric modulator (PAM).
MPEP also suppresses addiction-like behaviour for cocaine, ethanol and nicotine in various models of addiction. MPEP is blood-brain barrier (BBB) permeable and is active in vivo.
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Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in DMSO (100mM) and in ethanol (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-Methyl-6-(phenylethynyl)pyridine hydrochloride |
| Molecular Weight | 229.71 |
| Chemical structure | ![MPEP hydrochloride [219911-35-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0426.png "MPEP hydrochloride [219911-35-0]") |
| Molecular Formula | C14H11N.HCl |
| CAS Number | 219911-35-0 |
| PubChem identifier | 9794588 |
| SMILES | CC1=CC=CC(=N1)C#CC2=CC=CC=C2.Cl |
| Source | Synthetic |
| InChi | InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H |
| InChiKey | PKDHDJBNEKXCBI-UHFFFAOYSA-N |
| MDL number | MFCD02262119 |
| Appearance | White solid |
References for MPEP hydrochloride
References are publications that support the biological activity of the product
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Separate Ionotropic and Metabotropic Glutamate Receptor Functions in Depotentiation vs. LTP: A Distinct Role for Group1 mGluR Subtypes and NMDARs.
Latif-Hernandez et al (2016) Front Cell Neurosci. 7; : 10:252 -
Negative Allosteric Modulators of Metabotropic Glutamate Receptors Subtype 5 in Addiction: a Therapeutic Window.
Mihov and Hasler (2016) Int J Neuropsychopharmacol. 5; : 19(7) -
NMDA receptors, mGluR5, and endocannabinoids are involved in a cascade leading to hippocampal long-term depression.
Izumi and Zorumski (2012) Neuropsychopharmacology 37(3) : 609-17 -
2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist.
Gasparini F et al (1999) Neuropharmacology 38(10) : 1493-503.
Publications
These publications cite the use of MPEP hydrochloride purchased from Hello Bio:
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Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses
Tzounopoulos and Vogler (2018) bioRxiv doi : https://doi.org/10.1101/320671 -
Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors
Bellini et al (2017) bioRxiv : https://doi.org/10.1101/224477 -
PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.
Sweeny et al (2017) Sci Rep. 7 : 43606PubMedID: 28256580 -
Exploring the Role for mGluR5 in Regulating Striatal Medium Spiny Neuron Development
Bhagat, S. (2016) Duke Dissertations : 1-102
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