Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. A83-01 (HB3218)

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    Description:

    Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $92
    Qty:
    Pack:
    25mg
    Price:
    $310
    Qty:
  2. Pack:
    5mg
    Price:
    $320
    Qty:
    Pack:
    25mg
    Price:
    $1,049
    Qty:
  3. Arctigenin (HB0119)

    Description:

    Potent MAP kinase kinase (MKK/MEK) inhibitor

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $154
    Qty:
    Pack:
    50mg
    Price:
    $298
    Qty:
    Pack:
    100mg
    Price:
    $462
    Qty:
  4. 5-Azacytidine (HB1374)

    Description:

    DNA methyltransferase inhibitor. Improves stem cell reprogramming efficiency and induces differentiation of MSCs into cardiomyocytes.

    Purity:

    >98%

    Pack:
    50mg
    Price:
    $70
    Qty:
    Pack:
    250mg
    Price:
    $97
    Qty:
  5. BIO (HB1259)

    Description:

    Potent GSK-3α/β inhibitor. Maintains ESC self-renewal and pluripotency.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $292
    Qty:
    Pack:
    25mg
    Price:
    $653
    Qty:
  6. BIX 01294 (HB1413)

    Description:

    Potent, selective GLP / G9a HMTase inhibitor. Potentiates iPSC induction.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $215
    Qty:
    Pack:
    50mg
    Price:
    $751
    Qty:
  7. Pack:
    10mg
    Price:
    $102
    Qty:
    Pack:
    50mg
    Price:
    $378
    Qty:
  8. Description:

    Reversible protein transport inhibitor. Commonly used in cytokine staining. Enhances CRISPR-mediated HDR.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $110
    Qty:
    Pack:
    25mg
    Price:
    $481
    Qty:
  9. Pack:
    10μg
    Price:
    $182
    Qty:
  10. Description:

    Serine protease inhibitor. Inhibits TMPRSS2 and partially blocks SARS-Cov2 entry in vitro.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    Qty:
    Pack:
    50mg
    Price:
    $154
    Qty:
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