PI3K/Akt/mTOR

Highly potent, selective GluN2C/2D NMDAR antagonist

Potent, selective GluK1 subunit selective kainate receptor antagonist

Potent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist

NMDAR pan-PAM that potentiates all GluN2 subunits. Enhances LTD and decreases LTP. 

Ultrapotent PSEM agonist for PSAM⁴-GlyR and PSAM⁴-5HT3. Brain penetrant.

Endogenous hydrophilic bile acid. Antioxidant.

Histone deacetylase inhibitor. Shows multitude of biological actions. Enables pluripotent stem cell induction from somatic cells.

Potent BRAF and CRAF inhibitor

Serotonin/norepinephrine re-uptake inhibitor. Affects differentiation of NSCs.

L-type Ca²⁺ channel blocker