Electrophysiology and Patch Clamp Products – high quality, low cost
Ion Channel Modulators | GPCR Ligands | Transporter Ligands | Chemogenetic Compounds | Caged Compounds | Calcium Signalling Tools | Electrophysiology Buffers & Solutions
Patch clamp electrophysiology is a powerful technique used in neuroscience to study the electrical properties of individual neurons and their ion channels. By using a glass pipette to form a tight seal with a small patch of cell membrane, researchers can measure ionic currents with remarkable precision. This method allows scientists to investigate the fundamental mechanisms of synaptic transmission, neuronal excitability, and the effects of various drugs on cellular activity.
With decades of specialist experience in the manufacture of biochemicals & reagents for electrophysiology, Hello Bio offers a unique range, validated in electrophysiological studies, at around half the price of other suppliers.
Ion Channels
Voltage gated | Ligand Gated | Piezo | D-AP5 | TTX | CNQX
Blockers and activators for voltage-gated, ligand-gated, cyclic-nucleotide-gated & mechanosensitive ion channels. Potent & subtype selective modulators of calcium, potassium, sodium, chloride, proton & TRP channels.
G-Protein Coupled Receptors (GPCRs)
Adenosine | Adrenergic | mGluR | Opioid | Muscarinic | P2Y
Potent subtype-selective agonists, antagonists, positive allosteric modulators and negative allosteric modulators for G-protein-coupled receptors (GPCRs).
Transporters
GABA | Glutamate | Glycine | Monoamine | Cannabinoid
Potent and selective inhibitors and activators of P-type ATPases, F-type or V-type ATPases and ATP-binding cassette transporters.
Chemogenetics
DREADDS | PSEMS | CATKLAMP | CNO | DCZ
Unique range of high quality low cost chemogenetic compounds that are water soluble for easy use.
Caged Compounds
MNI-caged-L-Glutamate | RuBi-Glutamate | MNI-caged γ-DGG
The activity of our unique range of caged compounds is modulated by light - offering enhanced spatial and temporal control of their activation or inhibition of their biological target.
Calcium Signaling
Calcium Signalling | Ion Indicators and Ionophores | Fura-2-AM
Study Ca2+ signalling using our ion indicators (change color in response to ions), ionophores (facilitate ion transport) & chelators (bind ions)
Buffers and Solutions
aCSF Instant Powder (packets) | Cesium Gluconate
Use our premade solutions to save time and increase reproducibility: artificial cerebrospinal fluid (aCSF), solutions for creating brain slices (cutting solution) and internal solutions for filling a patch pipette.
Dyes Labels and Stains
Mounting Media | Fluorescent dyes | IHC stains | Protein labeling
Affordable reagents for tissue and cell imaging, for clear & reproducible staining results in immunohistochemistry (IHC) and fixed and live cell imaging experiments.
Antibodies
Neuroscience Markers | Loading Controls | Tags | Secondary
Affordable highly-validated & data-rich antibodies for western blot (WB), immunocytochemistry (ICC) and immunohistochemistry (IHC) to visualise specific target proteins.
Stem Cells
Differentiation | Organoids | Proliferation | Reprogramming
High quality small molecule pharmacological tools for manipulating signalling pathways during the in-vitro culture of stem cells & organoid generation.