MNI-caged γ-DGG (MNI-Caged γ-D-Glutamyl-Glycine)

Technical documents: CoA Datasheet

Product overview

Name MNI-caged γ-DGG (MNI-Caged γ-D-Glutamyl-Glycine)
Purity >98%

Novel caged, fast-equilibrating glutamate receptor antagonist. Suitable for use as a synaptic probe.

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Biological Data

Biological description

Novel, caged, fast-equilibrating version of the low-affinity competitive glutamate antagonist γ-DGG. Photo-release (e.g. by flashlamp or laser photolysis) releases γ-DGG. Photo-release of MNI-caged-γDGG (at concentrations up to 5mM) releases γ-DGG at concentrations up to 1.5mM in 1ms in wide-field flashlamp photolysis at climbing fiber-Purkinje cell (CF-PC) synapses without affecting (CF-PC) transmission. Photo-released γ-DGG has been shown to inhibit the CF- first and second paired EPSCs by ~30-60% respectively at concentrations of 0.55-1.7mM.

MNI-caged γ-DGG may be used as a synaptic probe as photolysis of MNI-caged γ-DGG resolves timing and extent of transmitter activation of receptors in glutamatergic transmission.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use



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Chemical Data

Purity >98%
Chemical name


Molecular Weight 380.35
Chemical structure MNI-DGG Chemical Structure
Molecular Formula C16H20N4O7
SMILES O=C(O)[C@H](N)CCC(=O)NCC(=O)N1CCc2c1c(ccc2OC)[N+]([O-])=O
Source Synthetic
InChi InChI=1S/C16H20N4O7/c1-27-12-4-3-11(20(25)26)15-9(12)6-7-19(15)14(22)8-18-13(21)5-2-10(17)16(23)24/h3-4,10H,2,5-8,17H2,1H3,(H,18,21)(H,23,24)/t10-/m1/s1
Appearance Yellow solid

References for MNI-caged γ-DGG (MNI-Caged γ-D-Glutamyl-Glycine)

References are publications that support the biological activity of the product
  • Photolysis of a Caged, Fast-Equilibrating Glutamate Receptor Antagonist, MNI-Caged γ-D-Glutamyl-Glycine, to Investigate Transmitter Dynamics and Receptor Properties at Glutamatergic Synapses.

    Palma-Cerda F et al (2018) Frontiers in cellular neuroscience 12 : 465

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