Technical documents: SDS CoA Datasheet
8  Reviews
Top Reviews:
100% of 100
Add Your Review

Product overview

Name MNI-caged-L-Glutamate
Alternative names MNI-Glu, Caged glutamate, MNI-Glutamate,
Purity >98%
Customer comments

We are very pleased to have such a company like yours that offers products like MNI-caged-glutamate (MNI-Glu) at a very good price and still with a high quality. So we will rate your product 5 stars! Verified customer

We confirmed Hello Bio MNI-caged-glutamate works very well for our two-photon uncaging experiment. I would be very happy to recommend your MNI glutamate. Verified customer

Works very well. We will be buying MNI-caged glutamate from Hello Bio from now on. We are happy that MNI-caged glutamate from Hello Bio works well for slice electrophysiological recordings in our focal laser stimulation experiments with DPSS laser (350nm). Verified customer

Description Caged glutamate that rapidly and efficiently releases glutamate when photolysed
Write Your Own Review
You're reviewing:MNI-caged-L-Glutamate
Rate this item:


MNI-caged-L-Glutamate: Scientist Approved
MNI-caged-L-Glutamate product vial image | Hello Bio

Biological Data

Biological description

Caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation).

Peak absorption is at 340 nm, the quantum yield is 0.085 and photo release following a light pulse has a half-time of 200 ns.

MNI-caged-L-Glutamate is inactive at glutamate receptors and transporters at mM concentrations but does interfere with synpatic activation of GABAA receptors (IC50 = ~0.5 mM).

MNI-caged-L-Glutamate is water soluble, resistant to hydrolysis and stable at neutral pH.

Solubility & Handling

Storage instructions -20°C (protect from light)
Solubility overview Soluble in water (50mM) with gentle warming

  • This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
  • Although stable to hydrolysis and soluble in water (50 mM) it is often necessary to warm stock solutions after thawing.

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Purity >98%
Chemical name (S)-α-Amino-2,3-dihydro-4-methoxy-7-nitro-δ-oxo-1H-indole-1-pentanoic acid
Molecular Weight 323.3
Chemical structure MNI-glutamate [295325-62-1] Chemical Structure
Molecular Formula C14H17N3O6
CAS Number 295325-62-1
PubChem identifier 6604871
SMILES COC1=C2CCN(C2=C(C=C1)[N+](=O)[O-])C(=O)CC[C@@H](C(=O)O)N
Source Synthetic
InChi 1S/C14H17N3O6/c1-23-11-4-3-10(17(21)22)13-8(11)6-7-16(13)12(18)5-2-9(15)14(19)20/h3-4,9H,2,5-7,15H2,1H3,(H,19,20)/t9-/m0/s1
Appearance Yellow solid

References for MNI-caged-L-Glutamate

References are publications that support the biological activity of the product
  • New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.

    Palma-Cerda et al (2012) Neuropharmacology 63(4) : 624-34
  • Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.

    Maier et al (2005) J Neurosci Methods 142(1) : 1-9
  • Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters.

    Canepari et al (2001) J Neurosci Methods 112(1) : 29-42

3 Item(s)

These publications cite the use of MNI-caged-L-Glutamate purchased from Hello Bio:
  • NMDAR-dependent supralinear dendritic integration in murine neurogliaform interneurons

    Griesius and Kullman (2024) bioRxiv
  • High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning.

    Getz AM et al (2022) Science advances 8 : eabm5298
    PubMedID: 35895810
  • FMRP regulates experience-dependent maturation of callosal synaptic connections and bilateral cortical synchrony

    Huber et al (2021) bioRxiv
  • Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

    Zhang Z et al (2021) Elife 10
    PubMedID: 34617509
  • Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula

    Nuno-Perez et al (2021) Neuron. 109(6) : 947-956
    PubMedID: 33535028

Items 1 to 5 of 6 total