Product overview
| Name | MNI-caged-L-Glutamate |
| Description | Caged glutamate that rapidly and efficiently releases glutamate when photolysed |
| Alternative names | MNI-Glu, Caged glutamate, MNI-Glutamate, |
| Purity | >98% |
| Customer comments | We are very pleased to have such a company like yours that offers products like MNI-caged-glutamate (MNI-Glu) at a very good price and still with a high quality. So we will rate your product 5 stars! Verified customer We confirmed Hello Bio MNI-caged-glutamate works very well for our two-photon uncaging experiment. I would be very happy to recommend your MNI glutamate. Verified customer Works very well. We will be buying MNI-caged glutamate from Hello Bio from now on. We are happy that MNI-caged glutamate from Hello Bio works well for slice electrophysiological recordings in our focal laser stimulation experiments with DPSS laser (350nm). Verified customer |
Images
Biological Data
| Biological description | Caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation). Peak absorption is at 340 nm, the quantum yield is 0.085 and photo release following a light pulse has a half-time of 200 ns.
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Solubility & Handling
| Storage instructions | -20°C (protect from light) |
| Solubility overview | Soluble in water (50mM) with gentle warming |
| Handling |
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| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | (S)-α-Amino-2,3-dihydro-4-methoxy-7-nitro-δ-oxo-1H-indole-1-pentanoic acid |
| Molecular Weight | 323.3 |
| Chemical structure | ![MNI-glutamate [295325-62-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0423_1.png "MNI-glutamate [295325-62-1]") |
| Molecular Formula | C14H17N3O6 |
| CAS Number | 295325-62-1 |
| PubChem identifier | 6604871 |
| SMILES | COC1=C2CCN(C2=C(C=C1)[N+](=O)[O-])C(=O)CC[C@@H](C(=O)O)N |
| Source | Synthetic |
| InChi | 1S/C14H17N3O6/c1-23-11-4-3-10(17(21)22)13-8(11)6-7-16(13)12(18)5-2-9(15)14(19)20/h3-4,9H,2,5-7,15H2,1H3,(H,19,20)/t9-/m0/s1 |
| InChiKey | GXIDBZKXGUNITQ-VIFPVBQESA-N |
| Appearance | Yellow solid |
References for MNI-caged-L-Glutamate
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New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.
Palma-Cerda et al (2012) Neuropharmacology 63(4) : 624-34 -
Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.
Maier et al (2005) J Neurosci Methods 142(1) : 1-9 -
Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters.
Canepari et al (2001) J Neurosci Methods 112(1) : 29-42
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High-resolution imaging and manipulation of endogenous AMPA receptor surface mobility during synaptic plasticity and learning.
Getz AM et al (2022) Science advances 8 : eabm5298PubMedID: 35895810 -
FMRP regulates experience-dependent maturation of callosal synaptic connections and bilateral cortical synchrony
Huber et al (2021) bioRxiv https://doi.org/10.1101/2021.06.25.449490 : doi -
Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP
Zhang Z et al (2021) Elife 10PubMedID: 34617509 -
Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula
Nuno-Perez et al (2021) Neuron. 109(6) : 947-956PubMedID: 33535028 -
Alterations in NMDAR-mediated signaling within the laterodorsal tegmental nucleus are associated with prenatal nicotine exposure
Polli FS et al (2019) Neuropharmacology 158 : 107744PubMedID: 31437434
Technical guides
Understanding purity and quality - a guide for life scientists
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