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Description
Caged glutamate that rapidly and efficiently releases glutamate when photolysed
MNI-caged-L-Glutamate product vial image | Hello Bio
MNI-caged-L-Glutamate: Scientist Approved
MNI-caged-L-Glutamate product vial image | Hello Bio
Biological Data
Biological description
Caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation).
Peak absorption is at 340 nm, the quantum yield is 0.085 and photo release following a light pulse has a half-time of 200 ns.
MNI-caged-L-Glutamate is inactive at glutamate receptors and transporters at mM concentrations but does interfere with synpatic activation of GABAA receptors (IC50 = ~0.5 mM).
MNI-caged-L-Glutamate is water soluble, resistant to hydrolysis and stable at neutral pH.
Solubility & Handling
Storage instructions
-20°C (protect from light)
Solubility overview
Soluble in water (50mM) with gentle warming
Handling
This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
Although stable to hydrolysis and soluble in water (50 mM) it is often necessary to warm stock solutions after thawing.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.
Palma-Cerda et al (2012) Neuropharmacology 63(4) : 624-34
![MNI-glutamate [295325-62-1] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0423_1.png "MNI-glutamate [295325-62-1]")
Understanding purity and quality - a guide for life scientists
