MNI-caged-L-Glutamate

(HB0423)
Technical documents: SDS CoA Datasheet

Product overview

Name MNI-caged-L-Glutamate
Description Caged glutamate that rapidly and efficiently releases glutamate when photolysed
Alternative names MNI-Glu, Caged glutamate, MNI-Glutamate,
Purity >98%
Customer comments

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We confirmed Hello Bio MNI-caged-glutamate works very well for our two-photon uncaging experiment. I would be very happy to recommend your MNI glutamate. Verified customer

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MNI-caged-L-Glutamate: Scientist Approved
MNI-caged-L-Glutamate vial

Biological Data

Biological description

Caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation).

Peak absorption is at 340 nm, the quantum yield is 0.085 and photo release following a light pulse has a half-time of 200 ns.


MNI-caged-L-Glutamate is inactive at glutamate receptors and transporters at mM concentrations but does interfere with synpatic activation of GABAA receptors (IC50 = ~0.5 mM).


MNI-caged-L-Glutamate is water soluble, resistant to hydrolysis and stable at neutral pH.

Solubility & Handling

Storage instructions -20°C (protect from light)
Solubility overview Soluble in water (50mM) with gentle warming
Handling

  • This compound is light sensitive; exposure to light may affect compound performance. We therefore recommend storing the material in the dark and protecting from light.
  • Although stable to hydrolysis and soluble in water (50 mM) it is often necessary to warm stock solutions after thawing.

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (S)-α-Amino-2,3-dihydro-4-methoxy-7-nitro-δ-oxo-1H-indole-1-pentanoic acid
Molecular Weight 323.3
Chemical structure MNI-glutamate [295325-62-1] Chemical Structure
Molecular Formula C14H17N3O6
CAS Number 295325-62-1
PubChem identifier 6604871
SMILES COC1=C2CCN(C2=C(C=C1)[N+](=O)[O-])C(=O)CC[C@@H](C(=O)O)N
Source Synthetic
InChi 1S/C14H17N3O6/c1-23-11-4-3-10(17(21)22)13-8(11)6-7-16(13)12(18)5-2-9(15)14(19)20/h3-4,9H,2,5-7,15H2,1H3,(H,19,20)/t9-/m0/s1
InChiKey GXIDBZKXGUNITQ-VIFPVBQESA-N
Appearance Yellow solid

References for MNI-caged-L-Glutamate

References are publications that support the biological activity of the product
  • New caged neurotransmitter analogs selective for glutamate receptor sub-types based on methoxynitroindoline and nitrophenylethoxycarbonyl caging groups.

    Palma-Cerda et al (2012) Neuropharmacology 63(4) : 624-34
  • Comparative analysis of inhibitory effects of caged ligands for the NMDA receptor.

    Maier et al (2005) J Neurosci Methods 142(1) : 1-9
  • Photochemical and pharmacological evaluation of 7-nitroindolinyl-and 4-methoxy-7-nitroindolinyl-amino acids as novel, fast caged neurotransmitters.

    Canepari et al (2001) J Neurosci Methods 112(1) : 29-42
Publications
These publications cite the use of MNI-caged-L-Glutamate purchased from Hello Bio:
  • Stress undermines reward-guided cognitive performance through synaptic depression in the lateral habenula

    Nuno-Perez et al (2021) Neuron. 109(6) : 947-956
    PubMedID: 33535028
  • Alterations in NMDAR-mediated signaling within the laterodorsal tegmental nucleus are associated with prenatal nicotine exposure

    Polli FS et al (2019) Neuropharmacology 158 : 107744
    PubMedID: 31437434

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