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Patch clamp electrophysiology is a powerful technique used in neuroscience to study the electrical properties of individual neurons and their ion channels. By using a glass pipette to form a tight seal with a small patch of cell membrane, researchers can measure ionic currents with remarkable precision. This method allows scientists to investigate the fundamental mechanisms of synaptic transmission, neuronal excitability, and the effects of various drugs on cellular activity.

Products for Electrophysiology

Researchers can save up to 50% on ion channel modulators, GPCR ligands, Transporter ligands, Chemogenetic compounds, caged compounds, calcium signalling tools and electrophysiology buffers and solutions from Hello Bio - they are up to half the price of other suppliers.


Ion Channels Voltage gated \| Ligand Gated \| Piezo \| D-AP5 \| TTX \| CNQX Ion channels are specialised pore-forming membrane proteins that allow ions to pass through the channel pore. They are classifed by their gating mechanism (eg. voltage-gated, ligand-gated, cyclic-nucleotide-gated & mechanosensitive) or ion selectivity (eg. calcium, potassium, sodium, chloride, proton).	G-Protein Coupled Receptors (GPCRs) Adenosine \| Adrenergic \| mGluR \| Opioid \| Muscarinic \| P2Y G-protein-coupled receptors (GPCRs), are integral membrane proteins coupled to heterotrimeric G proteins on the intracellular side of the cell membrane. Ligand binding causes a conformational change in the GPCR, that is then transmitted to the G protein, activating a signal transduction pathway.	Transporters GABA \| Glutamate \| Glycine \| Monoamine \| Cannabinoid Transporters are integral transmembrane proteins involved in the movement of ions, small molecules, peptides, lipids or macromolecules across a biological membrane. The three major classes of transporters are: P-type ATPases, F-type or V-type ATPases and ATP-binding cassette transporters.

Chemogenetics DREADDS \| PSEMS \| CATKLAMP \| CNO \| DCZ Chemogenetics research involves the use of small molecules that target genetically-modified receptors (DREADDs) or chimeric ion channels (PSAMs) to modulate and control neuronal activity. We supply a range of high quality low cost chemogenetic compounds that are water soluble for easy use.	Caged Compounds MNI-caged-L-Glutamate \| RuBi-Glutamate \| MNI-caged γ-DGG Caged compounds have their activity modulated by light. They contain a light sensitive chemical group which inactivates the molecule until it is "uncaged" through the application of light. This offers enhanced spatial and temporal control of their activation or inhibition of their biological target.	Calcium Signalling Calcium Signalling \| Ion Indicators and Ionophores \| Fura-2-AM Calcium ions regulate numerous neuronal processes through their ability to modulate a range of proteins including kinases, transcription factors and calmodulin (CaM). Ca²⁺ signalling is studied using ion indicators (change color in response to ions), ionophores (facilitate ion transport) & chelators (bind ions).

Buffers and Solutions aCSF Instant Powder (packets) \| Cesium Gluconate Electrophysiology requires a wide array of solutions such as artificial cerebrospinal fluid (aCSF), solutions for creating brain slices (cutting solution) and internal solutions for filling a patch pipette. Using our premade solutions saves both time and increases reproducibility.

Related Products for Electrophysiology

Dyes Labels and Stains

Mounting Media | Fluorescent dyes | IHC stains | Protein labeling

Hello Bio offers high quality yet affordable reagents for tissue and cell imaging, for clear & reproducible staining results in your immunohistochemistry (IHC) and fixed and live cell imaging experiments. Researchers can save up to 50% on cell imaging reagents, dyes, labels & stains from Hello Bio.

Antibodies

Neuroscience Markers | Loading Controls | Tags | Secondary

Antibodies are used in applications such as western blot (WB), immunocytochemistry (ICC) and immunohistochemistry (IHC) to visualise specific target proteins. Researchers can save time and money with Hello Bio's ValidAb™ range - highly-validated & data-rich antibodies at affordable prices.

Stem Cells

Differentiation | Organoids | Proliferation | Reprogramming

Small molecule pharmacological tools can be used to manipulate signalling pathways during the in-vitro culture of stem cells to grow, differentiatate into new cell types then maintain cell health. Researchers can save up to 50% on high purity stem cell research tools from Hello Bio.


Ion Channels Voltage gated \| Ligand Gated \| Piezo \| D-AP5 \| TTX \| CNQX Ion channels are specialised pore-forming membrane proteins that allow ions to pass through the channel pore. They are classifed by their gating mechanism (eg. voltage-gated, ligand-gated, cyclic-nucleotide-gated & mechanosensitive) or ion selectivity (eg. calcium, potassium, sodium, chloride, proton).	G-Protein Coupled Receptors (GPCRs) Adenosine \| Adrenergic \| mGluR \| Opioid \| Muscarinic \| P2Y G-protein-coupled receptors (GPCRs), are integral membrane proteins coupled to heterotrimeric G proteins on the intracellular side of the cell membrane. Ligand binding causes a conformational change in the GPCR, that is then transmitted to the G protein, activating a signal transduction pathway.	Transporters GABA \| Glutamate \| Glycine \| Monoamine \| Cannabinoid Transporters are integral transmembrane proteins involved in the movement of ions, small molecules, peptides, lipids or macromolecules across a biological membrane. The three major classes of transporters are: P-type ATPases, F-type or V-type ATPases and ATP-binding cassette transporters.

Chemogenetics DREADDS \| PSEMS \| CATKLAMP \| CNO \| DCZ Chemogenetics research involves the use of small molecules that target genetically-modified receptors (DREADDs) or chimeric ion channels (PSAMs) to modulate and control neuronal activity. We supply a range of high quality low cost chemogenetic compounds that are water soluble for easy use.	Caged Compounds MNI-caged-L-Glutamate \| RuBi-Glutamate \| MNI-caged γ-DGG Caged compounds have their activity modulated by light. They contain a light sensitive chemical group which inactivates the molecule until it is "uncaged" through the application of light. This offers enhanced spatial and temporal control of their activation or inhibition of their biological target.	Calcium Signalling Calcium Signalling \| Ion Indicators and Ionophores \| Fura-2-AM Calcium ions regulate numerous neuronal processes through their ability to modulate a range of proteins including kinases, transcription factors and calmodulin (CaM). Ca²⁺ signalling is studied using ion indicators (change color in response to ions), ionophores (facilitate ion transport) & chelators (bind ions).

Buffers and Solutions aCSF Instant Powder (packets) \| Cesium Gluconate Electrophysiology requires a wide array of solutions such as artificial cerebrospinal fluid (aCSF), solutions for creating brain slices (cutting solution) and internal solutions for filling a patch pipette. Using our premade solutions saves both time and increases reproducibility.