Mineralocorticoid

Selective, non-competitive AMPA / kainate receptor antagonist

Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist

Potent 5-HT₃ receptor antagonist. Also α7 nAChR partial agonist. Activates α7Q79G-GlyR chimeric ion channels.

Highly potent, selective GluN2C/2D NMDAR antagonist

Potent, selective GluK1 subunit selective kainate receptor antagonist

Potent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist

Potent, selective A_2A receptor antagonist