G protein coupled receptors
G-protein-coupled receptors (also known as GPCRs, transmembrane receptors, or 7-TM receptors), are integral membrane proteins that contain seven membrane-spanning domains (helices). They are coupled to heterotrimeric G proteins on the intracellular side of the cell membrane. Ligand binding causes a conformational change in the GPCR, that is then transmitted to the G protein, activating a signal transduction pathway. Researchers can save up to 50% on GPCR receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.
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Haloperidol hydrochloride (HB1842)
Description:Dopamine receptor antagonist with partial D2-like selectivity
Purity:>99%
ICI 182,780 (Fulvestrant) (HB2501)
Description:Estrogen receptor (ER) antagonist and high affinity GPER agonist
Purity:>99%
JNJ 10191584 maleate (HB1596)
Description:Potent, selective H4 receptor silent antagonist
Purity:>99%
LY-367385 hydrochloride (HB5153)
Description:Potent, highly selective mGlu1a antagonist. Water soluble.