My Cart
My account
Menu
Main Menu

Istradefylline

(HB2134)
Be the first to add a publication
Technical documents: CoA Datasheet
1  Review
Top Reviews:
100% of 100
Add Your Review
Add to Wish List

Product overview

Name Istradefylline
Alternative names KW-6002, ISD
Purity >98%
Description

Potent and selective A2A receptor antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (4) Frequently bought together
Write Your Own Review
You're reviewing:Istradefylline
Rate this item:

Biological Data

Biological description

Potent and selective A2A receptor antagonist (Ki values are 2.2 and 150 nM at A2A and A1 receptors respectively). Shows antiparkinsonian and anticataleptic effects. Also shown to reduce memory deficits in aging mice with amyloid pathology.

Solubility & Handling

Solubility overview Soluble in DMSO (20 mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione
Molecular Weight 384.43
Chemical structure Istradefylline [155270-99-8] Chemical Structure
Molecular Formula C20H24N4O4
CAS Number 155270-99-8
PubChem identifier 5311037
SMILES CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
InChi InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
InChiKey IQVRBWUUXZMOPW-PKNBQFBNSA-N
MDL number MFCD00928421

References for Istradefylline

References are publications that support the biological activity of the product

  • Istradefylline reduces memory deficits in aging mice with amyloid pathology

    Orr et al (2018) Neurobiol Dis. 110 : 29-36
    Read more (PubMedID: 29100987)

  • Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

    Boia et al (2017) Cell Death Dis. 8(10) : e3065
    PubMedID: 28981089

  • Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

    Shiozaki et al (1999) Psychopharmacology (Berl). 147(1) : 90-5
    Read more (PubMedID: 10591873)

  • Adenosine A2A antagonists with potent anti-cataleptic activity.

    Shimada et al (1997) Bioorg.Med.Chem.Lett. 7 : 2349

4 Item(s)

Related Products
Grouped product items
Order: HB2134
Pack PriceQty
10mg
$141
50mg
$595

Potent and selective A2A receptor antagonist

Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

Related Products

CA200623 CellAura fluorescent adenosine agonist [NECA]
Code:
HB7813
Pack:
50μg
Price:
$275
Fluorescent adenosine receptor agonist
CA200645 CellAura fluorescent adenosine A3 antagonist [XAC]
Code:
HB7812
Pack:
50μg
Price:
$275
Fluorescent A3 adenosine receptor antagonist
2-Chloroadenosine (CADO)
Code:
HB2844
Pack:
250mg, 1g
Price:
$337, $863
Adenosine receptor agonist