Istradefylline

(HB2134)
Technical documents: CoA Datasheet
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Product overview

Name Istradefylline
Alternative names KW-6002, ISD
Purity >98%
Description

Potent and selective A2A receptor antagonist

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Biological Data

Biological description

Potent and selective A2A receptor antagonist (Ki values are 2.2 and 150 nM at A2A and A1 receptors respectively). Shows antiparkinsonian and anticataleptic effects. Also shown to reduce memory deficits in aging mice with amyloid pathology.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (20 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione
Molecular Weight 384.43
Chemical structure Istradefylline [155270-99-8] Chemical Structure
Molecular Formula C20H24N4O4
CAS Number 155270-99-8
PubChem identifier 5311037
SMILES CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
InChi InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
InChiKey IQVRBWUUXZMOPW-PKNBQFBNSA-N
MDL number MFCD00928421

References for Istradefylline

References are publications that support the biological activity of the product
  • Istradefylline reduces memory deficits in aging mice with amyloid pathology

    Orr et al (2018) Neurobiol Dis. 110 : 29-36
  • Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage

    Boia et al (2017) Cell Death Dis. 8(10) : e3065
    PubMedID: 28981089
  • Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP

    Shiozaki et al (1999) Psychopharmacology (Berl). 147(1) : 90-5
  • Adenosine A2A antagonists with potent anti-cataleptic activity.

    Shimada et al (1997) Bioorg.Med.Chem.Lett. 7 : 2349

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