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Biological Data Biological description Potent and selective A2A receptor antagonist (Ki values are 2.2 and 150 nM at A2A and A1 receptors respectively). Shows antiparkinsonian and anticataleptic effects. Also shown to reduce memory deficits in aging mice with amyloid pathology.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (20 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name (E)-8-(3,4-Dimethoxystyryl)-1,3-diethyl-7-methyl-1H-purine-2,6(3H,7H)-dione
Chemical structure
Molecular Formula C20 H24 N4 O4
PubChem identifier 5311037
SMILES CCN1C2=C(C(=O)N(C1=O)CC)N(C(=N2)/C=C/C3=CC(=C(C=C3)OC)OC)C
InChi InChI=1S/C20H24N4O4/c1-6-23-18-17(19(25)24(7-2)20(23)26)22(3)16(21-18)11-9-13-8-10-14(27-4)15(12-13)28-5/h8-12H,6-7H2,1-5H3/b11-9+
InChiKey IQVRBWUUXZMOPW-PKNBQFBNSA-N
References for Istradefylline References are publications that support the biological activity of the product
Istradefylline reduces memory deficits in aging mice with amyloid pathology Orr et al (2018) Neurobiol Dis. 110 : 29-36 Treatment with A2A receptor antagonist KW6002 and caffeine intake regulate microglia reactivity and protect retina against transient ischemic damage Boia et al (2017) Cell Death Dis. 8(10) : e3065 PubMedID: 28981089
Actions of adenosine A2A receptor antagonist KW-6002 on drug-induced catalepsy and hypokinesia caused by reserpine or MPTP Shiozaki et al (1999) Psychopharmacology (Berl). 147(1) : 90-5 Adenosine A2A antagonists with potent anti-cataleptic activity. Shimada et al (1997) Bioorg.Med.Chem.Lett. 7 : 2349
Potent and selective A2A receptor antagonist
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