JNJ 16259685

Name: JNJ 16259685
Brand: Hello Bio
SKU: HB0348
Price: 192 USD
Availability: InStock

(HB0348)

Publications (4)

Technical documents: SDS CoA Datasheet

Product overview

Name

JNJ 16259685

Purity

>98%

Description

Potent, selective, non-competitive mGlu₁ antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Publications (4) References (4) Frequently bought together

Write Your Own Review

Images

JNJ 16259685 product vial image | Hello Bio

Biological Data

Biological description

Potent, selective and non-competitive mGlu₁ receptor antagonist (K_i = 0.34 nM at mGlu_1a).

Displays no activity at mGlu₂, mGlu₃, mGlu₄, mGlu₆, NMDA or AMPA receptors (IC₅₀ = >10 μM). Blood-brain barrier permeable.

Inhibits glutamate-induced Ca²⁺ mobilization (IC₅₀ = 3.24 nM at recombinant rat mGlu_1a receptor).

Decreases drug and alcohol addiction behaviours in rodents.

Solubility & Handling

Solubility overview

Soluble in ethanol (100mM) and in DMSO (25mM)

Storage instructions

+4°C

Storage of solutions

Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.

Shipping Conditions

Stable for ambient temperature shipping. Follow storage instructions on receipt.

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

(3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone

Molecular Weight

325.41

Chemical structure

Molecular Formula

C₂₀H₂₃NO₃

CAS Number

409345-29-5

PubChem identifier

11313361

SMILES

COC1CCC(CC1)C(=O)C2=CC3=CC4=C(N=C3C=C2)OCCC4

InChi

InChI=1S/C20H23NO3/c1-23-17-7-4-13(5-8-17)19(22)14-6-9-18-16(11-14)12-15-3-2-10-24-20(15)21-18/h6,9,11-13,17H,2-5,7-8,10H2,1H3

InChiKey

QOTAQTRFJWLFCR-UHFFFAOYSA-N

Appearance

Off-white solid

Technical guides

Metabotropic glutamate receptor (mGluR) mini-review

mGlu receptor (mGluR) associated proteins mini-review

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for JNJ 16259685

References are publications that support the biological activity of the product

mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.
Lum EN et al (2014) Neuropharmacology 79 : 679-87.
Read more (PubMedID: 24467847)
Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.
Xie X et al (2010) Psychopharmacology (Berl) 208(1) : 1-11.
Read more (PubMedID: 19847405)
Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.
Mabire D et al (2005) J Med Chem 48(6) : 2134-53.
Read more (PubMedID: 15771457)
JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.
Lavreysen H et al (2004) Neuropharmacology 47(7) : 961-72.
Read more (PubMedID: 15555631)

Publications

Submit Yours Now

These publications cite the use of JNJ 16259685 purchased from Hello Bio:

SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms
Hellyer et al (2023) bioRxiv https://www.biorxiv.org/content/10.1101/2023.07.05.545810v1.abstract
Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice
Kallergi E et al (2022) Nat Commun 13(1) : 680
PubMedID: 35115539
Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors
Pronot M et al (2022) Cell Mol Life Sci 79(7) : 378
PubMedID: 35739402
Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation
Kallergi et al. (2020) bioRxiv preprint : 1-46

Grouped product items
Order: HB0348
Pack	Price	Qty
10mg	$192
25mg	$441
50mg	$816

Request bulk discount

Potent, selective, non-competitive mGlu₁ antagonist

JNJ 16259685

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for JNJ 16259685

mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.

Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.

Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.

SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms

Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice

Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors

Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

About you

Tell us about your publication!

Captcha

JNJ 16259685

Product overview

Images

JNJ 16259685 product vial image | Hello Bio

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for JNJ 16259685

mGluR1 within the nucleus accumbens regulates alcohol intake in mice under limited-access conditions.

Effects of mGluR1 antagonism in the dorsal hippocampus on drug context-induced reinstatement of cocaine-seeking behavior in rats.

Synthesis, structure-activity relationship, and receptor pharmacology of a new series of quinoline derivatives acting as selective, noncompetitive mGlu1 antagonists.

JNJ16259685, a highly potent, selective and systemically active mGlu1 receptor antagonist.

SCA44- and SCAR13-associated GRM1 mutations affect metabotropic glutamate receptor 1 function through distinct mechanisms

Dendritic autophagy degrades postsynaptic proteins and is required for long-term synaptic depression in mice

Bidirectional regulation of synaptic SUMOylation by Group 1 metabotropic glutamate receptors

Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation

About you

Tell us about your publication!

Captcha

About you

How can we help you?

Related Products