Product overview
| Name | JNJ 10191584 maleate |
| Description | Potent, selective H4 receptor silent antagonist |
| Alternative names | VUF 6002 |
| Purity | >99% |
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Biological Data
| Biological description | Potent and selective H4 histamine receptor silent antagonist. Selective for human H4 over H3 by >540-fold (Ki values are 26 nM and 14.1 µM respectively). Inhibits chemotaxis of mast cells and eosinophils in vitro. Shows anti-inflammatory and antinociceptive actions. |
Solubility & Handling
| Storage instructions | room temperature (desiccate) |
| Solubility overview | Soluble in DMSO (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate |
| Molecular Weight | 394.81 |
| Chemical structure | ![JNJ 10191584 maleate [869497-75-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1596.png "JNJ 10191584 maleate [869497-75-6]") |
| Molecular Formula | C13H15ClN4O.C4H4O4 |
| CAS Number | 869497-75-6 |
| PubChem identifier | 11718163 |
| SMILES | O=C(O)/C=C\C(O)=O.ClC(C=C3)=CC2=C3N=C(N2)C(N1CCN(C)CC1)=O |
| InChiKey | KOTJFAYEELTYCZ-BTJKTKAUSA-N |
References for JNJ 10191584 maleate
References are publications that support the biological activity of the product
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Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.
Coruzzi G et al (2007) Eur J Pharmacol 563(1-3) : 240-4. -
Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.
Varga C et al (2005) Eur J Pharmacol 522(1-3) : 130-8. -
Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.
Venable JD et al (2005) J Med Chem 48(26) : 8289-98. -
Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.
Terzioglu N et al (2004) Bioorg Med Chem Lett 14(21) : 5251-6.
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