Potent and selective H4 histamine receptor silent antagonist. Selective for human H4 over H3 by >540-fold (Ki values are 26 nM and 14.1 µM respectively). Inhibits chemotaxis of mast cells and eosinophils in vitro. Shows anti-inflammatory and antinociceptive actions.
Solubility & Handling
Storage instructions
room temperature (desiccate)
Solubility overview
Soluble in DMSO (50mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.
Coruzzi G et al (2007) Eur J Pharmacol 563(1-3) : 240-4.
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