Potent and selective H4 histamine receptor silent antagonist. Selective for human H4 over H3 by >540-fold (Ki values are 26 nM and 14.1 µM respectively). Inhibits chemotaxis of mast cells and eosinophils in vitro. Shows anti-inflammatory and antinociceptive actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (50mM)
Storage instructions
room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.
Coruzzi G et al (2007) Eur J Pharmacol 563(1-3) : 240-4.
![JNJ 10191584 maleate [869497-75-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1596.png "JNJ 10191584 maleate [869497-75-6]")
Understanding purity and quality - a guide for life scientists
![CA200821 CellAura fluorescent H<sub>2</sub> antagonist [aminopotentidine]](https://cdn.hellobio.com/media/catalog/product/cache/5e99c5642d3d759e334623db25363a04/h/b/hb7825-ca200821-image1_1.jpg)
![CA200799 CellAura fluorescent H<sub>1</sub> antagonist [mepyramine]](https://cdn.hellobio.com/media/catalog/product/cache/5e99c5642d3d759e334623db25363a04/h/b/hb7824-ca200799-image1_1.png)
