Product overview

Name JNJ 10191584 maleate
Description Potent, selective H4 receptor silent antagonist
Alternative names VUF 6002
Purity >99%
Write Your Own Review
You're reviewing:JNJ 10191584 maleate
Rate this item:

Biological Data

Biological description Potent and selective H4 histamine receptor silent antagonist. Selective for human H4 over H3 by >540-fold (Ki values are 26 nM and 14.1 µM respectively). Inhibits chemotaxis of mast cells and eosinophils in vitro. Shows anti-inflammatory and antinociceptive actions.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Chemical name 1-[(5-Chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine maleate
Molecular Weight 394.81
Chemical structure JNJ 10191584 maleate  [869497-75-6] Chemical Structure
Molecular Formula C13H15ClN4O.C4H4O4
CAS Number 869497-75-6
PubChem identifier 11718163
SMILES O=C(O)/C=C\C(O)=O.ClC(C=C3)=CC2=C3N=C(N2)C(N1CCN(C)CC1)=O
InChiKey KOTJFAYEELTYCZ-BTJKTKAUSA-N

References for JNJ 10191584 maleate

References are publications that support the biological activity of the product
  • Antiinflammatory and antinociceptive effects of the selective histamine H4-receptor antagonists JNJ7777120 and VUF6002 in a rat model of carrageenan-induced acute inflammation.

    Coruzzi G et al (2007) Eur J Pharmacol 563(1-3) : 240-4.
  • Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat.

    Varga C et al (2005) Eur J Pharmacol 522(1-3) : 130-8.
  • Preparation and biological evaluation of indole, benzimidazole, and thienopyrrole piperazine carboxamides: potent human histamine h(4) antagonists.

    Venable JD et al (2005) J Med Chem 48(26) : 8289-98.
  • Synthesis and structure-activity relationships of indole and benzimidazole piperazines as histamine H(4) receptor antagonists.

    Terzioglu N et al (2004) Bioorg Med Chem Lett 14(21) : 5251-6.