Kinase
Protein kinases (phosphotransferases) are enzymes that catalyze phosphorylation. They phosphorylate specific amino acids using ATP as the source of phosphate. In this way, the biological activity of proteins is regulated; phosphorylation induces a conformational change from an inactive to an active form of the protein. Researchers can save up to 50% on kinase inhibitors and activators from Hello Bio - they are up to half the price of other suppliers.Â
View products: Akt / PKB | AMPK | Aurora kinase | BTK | CAM Kinase II | Casein kinase | CDK | c-Src | DYRK | ERK | GRK | GSK-3 | Hexokinase | JAK | MAPK | mTOR | Myosin light chain kinase (MLCK) | Non-selective | PKA | PKC | PKG | PI-3K | Protein-serine/threonine kinase | Protein-tyrosine kinase | RIP | ROCK | RSK| Sphingosine kinase | Syk |Raf | View Resources: Enzyme Inhibitors & Activators
CHIR 99021 (HB1261)
Description:Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.
Purity:>98%
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CHIR 99021 trihydrochloride (HB1262)
Description:Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons. Water soluble.
Purity:>98%
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DAPT (HB3345)
Description:γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.
Purity:>98%
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IWP 2 (HB0344)
Description:Potent Wnt pathway inhibitor and PORCN inhibitor. Suppresses R1 ESC self-renewal. Used in the production of cardiac organoids.
Purity:>98%
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IWP 4 (HB3066)
Description:Potent Wnt/β-catenin signaling inhibitor. Induces cardiomyocyte differentiation of hESCs and iPSCs.
Purity:>98%
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PD 0325901 (HB2240)
Description:Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.
Purity:>98%
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SB 202190 (HB1301)
Description:Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.
Purity:>99%
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SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%
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Trans-ISRIB (HB4567)
Description:Integrated stress response (ISR) inhibitor. Promotes pluripotent stem cell survival as part of the CEPT cocktail.
Purity:>98%
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ROCK inhibitor Y-27632 (HB2297)
Description:Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Purity:>99%
