Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Description:

    Phytohormone and endogenous lanthionine synthetase C-like 2 (LANCL2) ligand

    Purity:

    >99%

    Pack:
    10mg
    Price:
    $143
    Free trial
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    50mg
    Price:
    $626
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  2. 2  Reviews
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    Description:

    Artificial cerebrospinal fluid (aCSF)

    Pack:
    25mL
    Price:
    $106
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  3. Actinomycin D (HB1477)

    9  Reviews
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    Description:

    RNA polymerase inhibitor. Apoptosis inducer.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $129
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    5mg
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    Pack:
    100mg
    Price:
    $925
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    25mg
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    $243
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  4. Pack:
    5g
    Price:
    $49
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    Pack:
    25g
    Price:
    $166
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  5. Bafilomycin A1 (HB1125)

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    Description:

    Highly potent, selective V-ATPase inhibitor. Autophagy inhibitor.

    Purity:

    >98%

    Pack:
    10μg
    Price:
    $115
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    Pack:
    100μg
    Price:
    $316
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  6. Description:

    Reversible protein transport inhibitor. Commonly used in cytokine staining. Enhances CRISPR-mediated HDR.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $110
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    Pack:
    25mg
    Price:
    $481
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  7. Pack:
    1mg
    Price:
    $287
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  8. Pack:
    10μg
    Price:
    $182
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  9. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $50
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    Pack:
    2mg
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    Pack:
    5×2mg
    Price:
    $188
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    Pack:
    10mg
    Price:
    $182
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    Pack:
    5mg
    Price:
    $117
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    Pack:
    25mg
    Price:
    $445
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    Pack:
    50mg
    Price:
    $758
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    Pack:
    10mM (1mL in DMSO)
    Price:
    $126
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  10. Pack:
    1g
    Price:
    $34
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    Pack:
    5g
    Price:
    $100
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    Pack:
    10g
    Price:
    $179
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