Top Reviews:

100% of 100

LY367385

Name: LY367385
Brand: Hello Bio
SKU: HB0398
Price: 72 USD
Availability: InStock
Rating: 100 (2 reviews)

(HB0398)

Publications (6)

Technical documents: SDS CoA Datasheet

Product overview

Name

LY367385

Purity

>98%

Description

Potent, highly selective mGlu_1a antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Reviews (2) Publications (6) References (4) Frequently bought together

Write Your Own Review

Images

LY367385: Scientist Approved

Biological Data

Biological description

LY367385 is a potent, highly selective and competitive mGlu_1a receptor antagonist (IC₅₀ = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR₅ mediated responses). Water soluble version also available: LY-367385 hydrochloride.

LY367385 impairs induction and late phases of both long term potentiation (LTP) and long term depression (LTD) when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS).

LY367385 also displays antidepressant, anticonvulsant and neuroprotective actions.

Solubility & Handling

Storage instructions

Room temperature (desiccate)

Solubility overview

Soluble in 0.1M NaOH (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid

Molecular Weight

209.2

Chemical structure

Molecular Formula

C₁₀H₁₁NO₄

CAS Number

198419-91-9

PubChem identifier

5311261

SMILES

CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N

Source

Synthetic

InChi

InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1

InChiKey

SGIKDIUCJAUSRD-QMMMGPOBSA-N

MDL number

MFCD02262124

Appearance

Off-white solid

Technical guides

Metabotropic glutamate receptor (mGluR) mini-review

mGlu receptor (mGluR) associated proteins mini-review

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for LY367385

References are publications that support the biological activity of the product

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.
Neyman et al (2008) Eur J Neurosci 27(6) : 1345-52
Read more (PubMedID: 18364018)
Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.
Car H et al (2006) Pharmacol Rep 58(5) : 758-64.
Read more (PubMedID: 17085869)
Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).
Chapman AG et al (1999) Eur J Pharmacol 368(1) : 17-24.
Read more (PubMedID: 10096765)
Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept
Bruno V et al (1999) Neuropharmacology 38(2) : 199-207.
Read more (PubMedID: 10218860)

Publications

Submit Yours Now

These publications cite the use of LY367385 purchased from Hello Bio:

mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.
Valentinova and Mameli (2016) Cell Rep 16(9) : 2298-307
PubMedID: 27545888

Grouped product items
Order: HB0398
Pack	Price	Qty
5mg	$72
10mg	$136
25mg	$308
50mg	$598

Request bulk discount

Potent, highly selective mGlu_1a antagonist

New Products in this Area

LY-367385 hydrochloride

HB5153

Potent, highly selective mGlu_1a antagonist. Water soluble.

LY367385

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for LY367385

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.

Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept

mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

About you

Tell us about your publication!

Captcha

New Products in this Area

LY367385

Product overview

Images

LY367385: Scientist Approved

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for LY367385

Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.

Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept

mGluR-LTD at Excitatory and Inhibitory Synapses in the Lateral Habenula Tunes Neuronal Output.

About you

Tell us about your publication!

Captcha

About you

How can we help you?

New Products in this Area

Related Products