Product overview
| Name | (R,S)-3,5-DHPG |
| Description | Selective group I (mGluR1 / mGluR5) agonist |
| Alternative names | (RS)-3,5-Dihydroxyphenylglycine |
| Purity | >99% |
| Customer comments | Getting on well with DHPG & picrotoxin – they do what they’re supposed to! Professor Bruno Frenguelli, University of Warwick, UK |
Images
Biological Data
| Biological description | (R,S)-3,5-DHPG is a selective group I mGluR (mGluR1 / mGluR5) agonist.
(R,S)-3,5-DHPG also induces LTD in the hippocampus.
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Solubility & Handling
| Storage instructions | -20°C (desiccate). Protect from light. |
| Solubility overview | Soluble in water (10mM) |
| Handling | The compound is of high purity, however it is air sensitive and light promoted oxidation may cause slight discoloration of the compound. Product performance should not be affected, and this decolourisation can be ignored.
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| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (RS)-3,5-Dihydroxyphenylglycine |
| Molecular Weight | 183.16 |
| Chemical structure | ![(R,S)-3,5-DHPG [146255-66-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0026.png "(R,S)-3,5-DHPG [146255-66-5]") |
| Molecular Formula | C8H9NO4 |
| CAS Number | 146255-66-5 |
| PubChem identifier | 108001 |
| SMILES | C1=C(C=C(C=C1O)O)C(C(=O)O)N |
| Source | Synthetic |
| InChi | InChI=1S/C8H9NO4/c9-7(8(12)13)4-1-5(10)3-6(11)2-4/h1-3,7,10-11H,9H2,(H,12,13) |
| InChiKey | HOOWCUZPEFNHDT-UHFFFAOYSA-N |
| Appearance | White solid |
References for (R,S)-3,5-DHPG
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Interaction of DHPG-LTD and synaptic-LTD at senescent CA3-CA1 hippocampal synapses.
Kumar A et al (2014) Hippocampus 24(4) : 466-75. -
The group I mGlu receptor agonist DHPG induces a novel form of LTD in the CA1 region of the hippocampus.
Palmer MJ et al (1997) Neuropharmacology 36(11-12) : 1517-32. -
Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.
Pellegrini-Giampietro DE et al (1996) Br J Pharmacol 118(4) : 1035-43.
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Long-term synaptic depression triggers local biogenesis of autophagic vesicles in dendrites and requires autophagic degradation
Kallergi et al. (2020) bioRxiv preprint : 1-46 -
Probing the ionotropic activity of glutamate GluD2 receptor in HEK cells with genetically-engineered photopharmacology
Lemoine et al (2020) Elife 9: : e59026PubMedID: 33112237 -
Linking NMDA Receptor Synaptic Retention to Synaptic Plasticity and Cognition.
Franchini et al. (2019) iScience 19 : 927-939PubMedID: 31518901 -
Investigation into the role of the RNA methyltransferase NSun2 in neuroplasticity regulation
George, H. (2019) University of Bath Thesis : 1-230 -
The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.
Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646PubMedID: 30590038
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