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LY367385

(HB0398)
Publications (6)
Technical documents: SDS CoA Datasheet
2  Reviews
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Product overview

Name LY367385
Purity >98%
Description Potent, highly selective mGlu1a antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (3) Reviews (2) Publications (6) References (4) Frequently bought together
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LY367385: Scientist Approved
LY367385: Scientist Approved

LY367385: Scientist Approved

LY367385: Scientist Approved

Biological Data

Biological description

LY367385 is a potent, highly selective and competitive mGlu1a receptor antagonist (IC50 = 8.8 μM for blockade of quis-induced phosphoinositide (PI) hydrolysis, compared with >100μM for mGluR5 mediated responses). Water soluble version also available: LY-367385 hydrochloride.


LY367385 impairs induction and late phases of both long term potentiation (LTP) and long term depression (LTD) when applied before high-frequency tetanization (HFT) or low-frequency stimulation (LFS).


LY367385 also displays antidepressant, anticonvulsant and neuroprotective actions.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in 0.1M NaOH (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid
Molecular Weight 209.2
Chemical structure LY 367385 [198419-91-9] Chemical Structure
Molecular Formula C10H11NO4
CAS Number 198419-91-9
PubChem identifier 5311261
SMILES CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N
Source Synthetic
InChi InChI=1S/C10H11NO4/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15)/t8-/m0/s1
InChiKey SGIKDIUCJAUSRD-QMMMGPOBSA-N
MDL number MFCD02262124
Appearance Off-white solid

References for LY367385

References are publications that support the biological activity of the product

  • Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro.

    Neyman et al (2008) Eur J Neurosci 27(6) : 1345-52
    Read more (PubMedID: 18364018)

  • Antidepressant-like effects of baclofen and LY367385 in the forced swim test in rats.

    Car H et al (2006) Pharmacol Rep 58(5) : 758-64.
    Read more (PubMedID: 17085869)

  • Anticonvulsant actions of LY 367385 ((+)-2-methyl-4-carboxyphenylglycine) and AIDA ((RS)-1-aminoindan-1,5-dicarboxylic acid).

    Chapman AG et al (1999) Eur J Pharmacol 368(1) : 17-24.
    Read more (PubMedID: 10096765)

  • Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (LY367385): comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 recept

    Bruno V et al (1999) Neuropharmacology 38(2) : 199-207.
    Read more (PubMedID: 10218860)

4 Item(s)

Publications
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These publications cite the use of LY367385 purchased from Hello Bio:

  • Mechanisms of synaptic zinc plasticity at mouse dorsal cochlear nucleus glutamatergic synapses

    Tzounopoulos and Vogler (2018) bioRxiv doi : https://doi.org/10.1101/320671

  • The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression.

    Sanderson et al (2018) Cell Rep. 25(13) : 3631-3646
    PubMedID: 30590038

  • Presynaptic mGluR5 receptor controls glutamatergic input through protein kinase C-NMDA receptors in pac-induced neuropathic pain.

    Xie et al (2017) J Biol Chem pii: jbc.M117.818476. : doi: 10.1074/jbc.M117.818476.
    PubMedID: 29074619

  • Neuronal glutamate transporters control dopaminergic signaling and compulsive behaviors

    Bellini et al (2017) bioRxiv : https://doi.org/10.1101/224477

  • PAR1 activation induces rapid changes in glutamate uptake and astrocyte morphology.

    Sweeny et al (2017) Sci Rep. 7 : 43606
    PubMedID: 28256580

Items 1 to 5 of 6 total

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Order: HB0398
Pack PriceQty
5mg
$72
10mg
$136
25mg
$308
50mg
$598
Potent, highly selective mGlu1a antagonist
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