My Cart
My account
Menu
Main Menu

Forskolin

(HB1348)
Publications (9)
Technical documents: SDS CoA Datasheet
5  Reviews
Top Reviews:
100% of 100
Add Your Review
Add to Wish List

Product overview

Name Forskolin
Purity >98%
Customer comments

I am currently working with forskolin. The quality of product and service is very satisfying. I am very happy to have access to your high quality products. Pojeong Park, PhD student, University of Bristol, UK

Very satisfied with this product, it works as expected in our liver tumouroid cultures. Hello Bio are a fantastic company that keep you informed of your order throughout the delivery process. Also a fan of the datasheets they provide. Verified customer, UK

Description Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews (5) Publications (9) References (4) Frequently bought together
Write Your Own Review
You're reviewing:Forskolin
Rate this item:

Images

Figure. 1 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Figure. 1 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Figure. 2 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Figure. 2 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Figure. 3 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Figure. 3 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Forskolin product vial image | Hello Bio
Forskolin product vial image | Hello Bio
Figure. 1 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Figure. 1 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Figure. 2 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Figure. 2 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)
Figure. 3 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Figure. 3 Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Liver hepatocellular carcinoma tumouroids cultured with A83-01 (HB3218) and Forskolin (HB1348)

Forskolin product vial image | Hello Bio

Forskolin product vial image | Hello Bio

Biological Data

Biological description

Cell permeable, reversible adenylyl cyclase activator which increases cAMP levels and inhibits platelet-activating factor (PAF).

Inhibits mast cell degranulation and lowers intraocular pressure. Also displays vasodilating and hypotensive properties.

It is used as a neuronal differentiation inducer, used as a 3D Growth matrix component and used in the production of liver organoids. Forskolin, in combination with the 2i inhibitors (CHIR 99021 & PD 0325901), and LIF is sufficient to transform hESCs to a naive, mouse embryonic-like state.

 

Application notes

Figures 1 - 3 show liver hepatocellular carcinoma tumouroids cultured with forskolin and A 83-01

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (25 mM)
Handling

Cell culture media can be prewarmed before adding the compound to avoid potential precipitation of the compound.

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name [3R-(3<α,4aβ,5β,6β,6aα,10α,10aβ,10bα)]-5-(Acetyloxy)-3-ethenyldodecahydro-6,10,10b-trihydroxy-3,4a,7,7,10a-pentamethyl-1H-naphtho[2,1-b]pyran-1-one
Molecular Weight 410.51
Chemical structure Forskolin [66575-29-9] Chemical Structure
Molecular Formula C22H34O7
CAS Number 66575-29-9
PubChem identifier 47936
SMILES CC(=O)O[C@H]1[C@H]([C@@H]2[C@]([C@H](CCC2(C)C)O)([C@@]3([C@@]1(O[C@@](CC3=O)(C)C=C)C)O)C)O
InChi InChI=1S/C22H34O7/c1-8-19(5)11-14(25)22(27)20(6)13(24)9-10-18(3,4)16(20)15(26)17(28-12(2)23)21(22,7)29-19/h8,13,15-17,24,26-27H,1,9-11H2,2-7H3/t13-,15-,16-,17-,19-,20-,21+,22-/m0/s1
InChiKey OHCQJHSOBUTRHG-KGGHGJDLSA-N
MDL number MFCD00082317

References for Forskolin

References are publications that support the biological activity of the product

  • Forskolin and derivatives as tools for studying the role of cAMP.

    Alasbahi RH et al (2012) Pharmazie 67(1) : 5-13.
    Read more (PubMedID: 22393824)

  • Forskolin: upcoming antiglaucoma molecule.

    Wagh VD et al (2012) J Postgrad Med 58(3) : 199-202.
    Read more (PubMedID: 23023353)

  • Forskolin as a tool for examining adenylyl cyclase expression, regulation, and G protein signaling.

    Insel PA et al (2003) Cell Mol Neurobiol 23(3) : 305-14.
    Read more (PubMedID: 12825829)

  • Interactions of forskolin and adenylate cyclase. Effects on substrate kinetics and protection against inactivation by heat and N-ethylmaleimide.

    Awad JA et al (1983) J Biol Chem 258(5) : 2960-5.
    Read more (PubMedID: 6681815)

4 Item(s)

Publications
Submit Yours Now
These publications cite the use of Forskolin purchased from Hello Bio:

  • Activation of μ-opioid receptors by MT-45 (1-cyclohexyl-4-(1,2-diphenylethyl)piperazine) and its fluorinated derivatives

    Baptista-Hon DT et al (2020) Br J Pharmacol 177(15) : 3436-3448
    PubMedID: 32246840

  • Differential regulation of prelimbic and thalamic transmission to the basolateral amygdala by acetylcholine receptors

    Tryon et al (2019) University of Columbia : Thesis

  • The readily-releasable pool dynamically regulates multivesicular release

    Vaden et al (2019) eLife : 8
    PubMedID: 31364987

  • RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain

    Robinson BG et al (2019) Elife 8
    PubMedID: 31486769

Items 6 to 9 of 9 total

Page
Related Products
Grouped product items
Order: HB1348
Pack PriceQty
10mg
$124
50mg
$523
Cell permeable, reversible adenylyl cyclase activator. Neuronal differentiation inducer. Used in production of liver organoids.
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

New Products in this Area

Pexidartinib (PLX3397)
HB8991

Potent CSF-1R inhibitor. Widely used microglia-depletion agent.

Related Products

ROCK inhibitor Y-27632
Code:
HB2297
Pack:
1mg, 2mg, 5mg, 10mg, 5x10mg, 25mg, 50mg, 10mM solution (in 1mL DMSO), 50mM (add 1ml water), 100mM (add 1ml water)
Price:
$44, $69, $119, $168, $754, $325, $564, $172, $408, $680
(Free trial)

Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.

NKH 477
Code:
HB2932
Pack:
10mg, 50mg
Price:
$171, $660
Potent, water-soluble adenylyl cyclase activator
A83-01
Code:
HB3218
Pack:
5mg, 25mg
Price:
$88, $297
Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self...