Product overview

Name NKH 477
Description Potent, water-soluble adenylyl cyclase activator
Biological description

Potent, orally active, cell permeable and BBB permeable adenylyl cyclase activator. Water-soluble derivative of forskolin.

~1.87-fold more potent than Forskolin at stimulating insect cell membrane type V adenylate cyclase (AC) activity, while exhibiting similar potency at type II & III AC isoforms.

Also shows bronchodilatory, antidepressant and hyoptensive properties in vivo.

Alternative names Colforsin daropate hydrochloride
Purity >98%
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Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in water (40mM) and DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Chemical Data

Chemical name N,N-Dimethyl-(3R,4aR,5S,6aS,10S,10aR,10bS)-5-(acetyloxy)-3-ethenyldodecahydro-10,10b-dihydroxy-3,4a,7,7,10a-pentamethyl-1-oxo-1H-naphtho[2,1-b]pyran-6-yl ester β-alanine hydrochloride
Molecular Weight 546.09
Chemical structure Product image
Molecular Formula C27H43NO8.HCl
CAS Number 138605-00-2
PubChem identifier 444028
SMILES Cl.CN(C)CCC(=O)O[C@@H]1[C@H](OC(C)=O)[C@@]3(C)O[C@@](C)(C=C)CC(=O)[C@]3(O)[C@@]2(C)[C@@H](O)CCC(C)(C)[C@H]12
Source Synthetic
InChi InChI=1S/C27H43NO8.ClH/c1-10-24(5)15-18(31)27(33)25(6)17(30)11-13-23(3,4)21(25)20(35-19(32)12-14-28(8)9)22(34-16(2)29)26(27,7)36-24;/h10,17,20-22,30,33H,1,11-15H2,2-9H3;1H/t17-,20-,21-,22-,24-,25-,26+,27-;/m0./s1
InChiKey VIRRLEDAYYYTOD-YHEOSNBFSA-N
MDL number MFCD00236421
Appearance White solid

References for NKH 477

References are publications that support the biological activity of the product
  • Behavioural effects of NKH-477, a forskolin analogue, on locomotion and rearing in rats

    Kofman and Bersudsky (2000) Int J Neuropsychopharmacol. 3(1) : 27-33
  • Cardiovascular and adenylate cyclase stimulant properties of NKH477, a novel water-soluble forskolin derivative

    Hosono et al (1992) J Cardiovasc Pharmacol 19(4) : 625-34.
  • Forskolin derivatives with increased selectivity for cardiac adenylyl cyclase

    Toya et al (1998) J Mol Cell Cardiol. 30(1) : 97-108