Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
Troglitazone (HB2559)
Description:Potent, selective PPARγ agonist. Inhibits hematopoietic cell line growth.
Purity:>97%
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uPSEM792 hydrochloride (HB8542)
Description:Ultrapotent PSEM agonist for PSAM4-GlyR and PSAM4-5HT3. Brain penetrant.
Purity:>99%
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uPSEM817 tartrate (HB8620)
Description:Selective, ultrapotent PSEM agonist for PSAM4-GlyR and PSAM4-5HT3. Brain penetrant.
Purity:>99%
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Varenicline tartrate (HB2070)
Description:Selective α4β2 nAChR partial agonist; orally active
Purity:>99%
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VU 0357017 hydrochloride (HB1498)
Description:Potent, selective M1 receptor allosteric agonist
Purity:>98%
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