The store will not work correctly in the case when cookies are disabled.
Biological Data
| Biological description | Subtype-selective α4β2 nicotinic receptor partial agonist (Ki values are 0.06, 240, 322 and 3540 nM for α4β2, α3β4, α7, α1βγδ receptors respectively).
Also activates PSAM4-5HT3 and PSAM4-GlyR (EC50 values are 4 nM and 1.6 nM respectively) chimeric ion channels to silence neurons.
Stimulates dopamine release. Orally active. Shows excellent brain penetrance.
|
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (100 mM), and in DMSO (50 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 7,8,9,10-Tetrahydro-6,10-methano-6H-pyrazino [2,3-h][3] benzazepine tartrate |
| Chemical structure |  |
| Molecular Formula | C13H13N3.C4H6O6 |
| PubChem identifier | 9906942 |
| SMILES | C1C2CNCC1C3=CC4=NC=CN=C4C=C23.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O |
| InChi | InChI=1S/C13H13N3.C4H6O6/c1-2-16-13-5-11-9-3-8(6-14-7-9)10(11)4-12(13)15-1;5-1(3(7)8)2(6)4(9)10/h1-2,4-5,8-9,14H,3,6-7H2;1-2,5-6H,(H,7,8)(H,9,10)/t;1-,2-/m.1/s1 |
| InChiKey | JQSHBVHOMNKWFT-DTORHVGOSA-N |
References for Varenicline tartrate
References are publications that support the biological activity of the product
-
Ultrapotent chemogenetics for research and potential clinical applications
Magnus CJ et al (2019) Science 364 : (6436) -
Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid
Rollema H et al (2007) Neuropharmacology 52(3) : 985-94 -
Varenicline is a partial agonist at alpha4beta2 and a full agonist at alpha7 neuronal nicotinic receptors.
Mihalak et al (2006) Mol Pharmacol. 70(3) : 801-5
Selective α4β2 nAChR partial agonist; orally active
Understanding purity and quality - a guide for life scientists
