Target

Potent and selective orexin OX₂ antagonist

AT₁ antagonist and PPARγ partial agonist

Adenosine receptor antagonist

Selective GluK1 kainate receptor antagonist

Potent 5-HT₃ receptor antagonist. Also α7 nAChR partial agonist. Activates α7Q79G-GlyR chimeric ion channels.

Nicotinic acetylcholine receptors (nACHR) antagonist. Neuromuscular blocker.

Selective antagonist for GluN2D subunit containing NMDA receptors

Highly potent, selective GluN2C/2D NMDAR antagonist

Potent, selective GluK1 subunit selective kainate receptor antagonist

Potent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist