Potent, selective orexin-2 receptor antagonist (IC50= 40 nM) which displays >250-fold selectivity for OX2 over OX1 and over 50 other receptors, ion channels and transporters. Shows various biological effects. Active in vivo.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in water (100 mM), and in DMSO (10 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References are publications that support the biological activity of the product
Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.
Brown RM et al (2013) The international journal of neuropsychopharmacology 16 : 2067-79
Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats.
Azhdari-Zarmehri H et al (2013) Peptides 47 : 94-8
![TCS OX2 29 [1610882-30-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb3225_1.png "TCS OX2 29 [1610882-30-8]")
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