Potent, selective orexin-2 receptor antagonist (IC50= 40 nM) which displays >250-fold selectivity for OX2 over OX1 and over 50 other receptors, ion channels and transporters. Shows various biological effects. Active in vivo.
Solubility & Handling
Solubility overview
Soluble in water (100 mM), and in DMSO (10 mM)
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
References are publications that support the biological activity of the product
Central orexin (hypocretin) 2 receptor antagonism reduces ethanol self-administration, but not cue-conditioned ethanol-seeking, in ethanol-preferring rats.
Brown RM et al (2013) The international journal of neuropsychopharmacology 16 : 2067-79
Involvement of orexin-2 receptors in the ventral tegmental area and nucleus accumbens in the antinociception induced by the lateral hypothalamus stimulation in rats.
Azhdari-Zarmehri H et al (2013) Peptides 47 : 94-8
![TCS OX2 29 [1610882-30-8] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb3225_1.png "TCS OX2 29 [1610882-30-8]")
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