UBP145

Name: UBP145
Brand: Hello Bio
SKU: HB4717
Price: 167 USD
Availability: InStock

(HB4717)

Publications (1)

Technical documents: SDS CoA Datasheet

Product overview

Name

UBP145

Alternative names

UBP-145

Purity

>97%

Description

Selective antagonist for GluN2D subunit containing NMDA receptors

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Publications (1) References (5) Frequently bought together

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Biological Data

Biological description

Selective antagonist for GluN2D subunit containing NMDA receptors. Binds competitively at the glutamate site.

Displays ~10- fold selectivity for GluN2D-containing receptors over GluN2B (NR2B) or GluN2A (NR2A) containing receptors (K_i values are 1.19, 7.99 and 11.53 at GluN1/GluN2D, GluN1/GluN2B and GluN1/GluN2A containing receptors respectively).

Inhibits synaptic NMDAR response.

Solubility & Handling

Storage instructions

-20°C

Solubility overview

Soluble in DMSO (100mM, gentle warming)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>97%

Chemical name

1-(9-bromophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid

Molecular Weight

457.28

Chemical structure

Molecular Formula

C₂₁H₁₇BrN₂O₅

PubChem identifier

56945293

SMILES

C1CN([C@H]([C@H](N1)C(=O)O)C(=O)O)C(=O)C2=CC3=C(C=C2)C=C(C4=CC=CC=C43)Br

Source

Synthetic

InChi

InChI=1S/C21H17BrN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1

InChiKey

HUVFBBHRFWAJAA-ZWKOTPCHSA-N

Appearance

Off-white solid

Technical guides

NMDA receptor (NMDAR) mini-review

NMDA receptor (NMDAR) associated proteins mini-review

Ionotropic glutamate receptor nomenclature guide

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for UBP145

References are publications that support the biological activity of the product

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators
France et al (2022) Neuropharmacology : 202:108840
Read more (PubMedID: 34678377)
Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices
Eapen et al (2021) Neuropharmacology . 108833 : 201
Read more (PubMedID: 34637787)
GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.
Hildebrand et al (2014) Sci Rep 13 : 4-4094
Read more (PubMedID: 24522697)
Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.
Volianskis et al (2013) J Physiol. 591(4) : 955-72
Read more (PubMedID: 23230236)
N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse.
Costa et al (2009) J Pharmacol Exp Ther 331(2) : 618-26
Read more (PubMedID: 19684252)

Publications

Submit Yours Now

These publications cite the use of UBP145 purchased from Hello Bio:

NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice
Xue M et al (2021) Mol Pain 17 : 1.74481E+16
PubMedID: 34024172

Selective antagonist for GluN2D subunit containing NMDA receptors

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Order: HB4717
Pack	Price	Qty
10mg	$167

UBP145

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for UBP145

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices

GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.

N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse.

NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice

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UBP145

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for UBP145

Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices

GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.

Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.

N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse.

NMDA Receptor-Dependent Synaptic Depression in Potentiated Synapses of the Anterior Cingulate Cortex of adult Mice

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