Selective antagonist for GluN2D subunit containing NMDA receptors. Binds competitively at the glutamate site.
Displays ~10- fold selectivity for GluN2D-containing receptors over GluN2B (NR2B) or GluN2A (NR2A) containing receptors (Ki values are 1.19, 7.99 and 11.53 at GluN1/GluN2D, GluN1/GluN2B and GluN1/GluN2A containing receptors respectively).
Inhibits synaptic NMDAR response.
Solubility & Handling
Soluble in DMSO (100mM, gentle warming)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse.
Costa et al (2009) J Pharmacol Exp Ther 331(2) : 618-26