Product overview

Name UBP145
Description Selective antagonist for GluN2D subunit containing NMDA receptors
Alternative names UBP-145
Purity >98%
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Biological Data

Biological description

Selective antagonist for GluN2D subunit containing NMDA receptors. Binds competitively at the glutamate site.

Displays ~10- fold selectivity for GluN2D-containing receptors over GluN2B (NR2B) or GluN2A (NR2A) containing receptors (Ki values are 1.19, 7.99 and 11.53 at GluN1/GluN2D, GluN1/GluN2B and GluN1/GluN2A containing receptors respectively).

Inhibits synaptic NMDAR response.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM, gentle warming)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-(9-bromophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid
Molecular Weight 457.28
Chemical structure UBP 145 Chemical Structure
Molecular Formula C21H17BrN2O5
PubChem identifier 56945293
SMILES C1CN([C@H]([C@H](N1)C(=O)O)C(=O)O)C(=O)C2=CC3=C(C=C2)C=C(C4=CC=CC=C43)Br
Source Synthetic
InChi InChI=1S/C21H17BrN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1
InChiKey HUVFBBHRFWAJAA-ZWKOTPCHSA-N
Appearance Off-white solid

References for UBP145

References are publications that support the biological activity of the product
  • Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

    France et al (2022) Neuropharmacology : 202:108840
  • Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices

    Eapen et al (2021) Neuropharmacology . 108833 : 201
  • GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.

    Hildebrand et al (2014) Sci Rep 13 : 4-4094
  • Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.

    Volianskis et al (2013) J Physiol. 591(4) : 955-72
  • N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse.

    Costa et al (2009) J Pharmacol Exp Ther 331(2) : 618-26