Product overview
| Name | UBP145 |
| Description | Selective antagonist for GluN2D subunit containing NMDA receptors |
| Alternative names | UBP-145 |
| Purity | >98% |
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Biological Data
| Biological description | Selective antagonist for GluN2D subunit containing NMDA receptors. Binds competitively at the glutamate site. Displays ~10- fold selectivity for GluN2D-containing receptors over GluN2B (NR2B) or GluN2A (NR2A) containing receptors (Ki values are 1.19, 7.99 and 11.53 at GluN1/GluN2D, GluN1/GluN2B and GluN1/GluN2A containing receptors respectively). Inhibits synaptic NMDAR response. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-(9-bromophenanthrene-3-carbonyl)piperazine-2,3-dicarboxylic acid |
| Molecular Weight | 457.28 |
| Chemical structure |  |
| Molecular Formula | C21H17BrN2O5 |
| PubChem identifier | 56945293 |
| SMILES | C1CN([C@H]([C@H](N1)C(=O)O)C(=O)O)C(=O)C2=CC3=C(C=C2)C=C(C4=CC=CC=C43)Br |
| Source | Synthetic |
| InChi | InChI=1S/C21H17BrN2O5/c22-16-10-11-5-6-12(9-15(11)13-3-1-2-4-14(13)16)19(25)24-8-7-23-17(20(26)27)18(24)21(28)29/h1-6,9-10,17-18,23H,7-8H2,(H,26,27)(H,28,29)/t17-,18+/m0/s1 |
| InChiKey | HUVFBBHRFWAJAA-ZWKOTPCHSA-N |
| Appearance | Off-white solid |
References for UBP145
References are publications that support the biological activity of the product
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Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators
France et al (2022) Neuropharmacology : 202:108840 -
Multiple roles of GluN2D-containing NMDA receptors in short-term potentiation and long-term potentiation in mouse hippocampal slices
Eapen et al (2021) Neuropharmacology . 108833 : 201 -
GluN2B and GluN2D NMDARs dominate synaptic responses in the adult spinal cord.
Hildebrand et al (2014) Sci Rep 13 : 4-4094 -
Different NMDA receptor subtypes mediate induction of long-term potentiation and two forms of short-term potentiation at CA1 synapses in rat hippocampus in vitro.
Volianskis et al (2013) J Physiol. 591(4) : 955-72 -
N-methyl-D-aspartate (NMDA) receptor NR2 subunit selectivity of a series of novel piperazine-2,3-dicarboxylate derivatives: preferential blockade of extrasynaptic NMDA receptors in the rat hippocampal CA3-CA1 synapse.
Costa et al (2009) J Pharmacol Exp Ther 331(2) : 618-26
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- Code:
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Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs