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Telmisartan

(HB2558)
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Product overview

Name Telmisartan
Alternative names BIBR 277
Purity >98%
Description AT1 antagonist and PPARγ partial agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description

AT1 (Angiotensin II receptor type 1) antagonist / blocker (Ki = 3.7 nM). It is also a PPARγ partial agonist.

Shows anti-hypertensive effects.

Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Solubility overview Soluble in DMSO (20mM)
Storage instructions RT
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name 2-(4-{[4-Methyl-6-(1-methyl-1H-1,3-benzodiazol-2-yl)-2-propyl-1H-1,3-benzodiazol-1-yl]methyl}phenyl)benzoic acid
Molecular Weight 514.62
Chemical structure Telmisartan [144701-48-4] Chemical Structure
Molecular Formula C33H30N4O2
CAS Number 144701-48-4
PubChem identifier 65999
SMILES O=C(O)c1ccccc1c2ccc(cc2)Cn3c4cc(cc(c4nc3CCC)C)c5nc6ccccc6n5C
InChi InChI=1S/C33H30N4O2/c1-4-9-30-35-31-21(2)18-24(32-34-27-12-7-8-13-28(27)36(32)3)19-29(31)37(30)20-22-14-16-23(17-15-22)25-10-5-6-11-26(25)33(38)39/h5-8,10-19H,4,9,20H2,1-3H3,(H,38,39)
InChiKey RMMXLENWKUUMAY-UHFFFAOYSA-N
MDL number MFCD00918125
Appearance White solid

References for Telmisartan

References are publications that support the biological activity of the product

  • Telmisartan as tentative angiotensin receptor blocker therapeutic for COVID-19

    Rothlin et al (2020) Drug Dev Res. 1l10 : 1002
    Read more (PubMedID: 32356926)

  • 6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships

    Ries et al (1993) J Med Chem 36(25) : 4040-51
    Read more (PubMedID: 8258826)

  • Pharmacological characterization of the novel nonpeptide angiotensin II receptor antagonist, BIBR 277

    Wienen et al (1993) Br J Pharmacol. 110(1) : 245-52.
    Read more (PubMedID: 8220885)

3 Item(s)

Related Products
Grouped product items
Order: HB2558
Pack PriceQty
10mg
$42
50mg
$106
AT1 antagonist and PPARγ partial agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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