Product overview

Name Topiramate
Description Selective GluK1 kainate receptor antagonist
Alternative names Topamax
Purity >99%
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Biological Data

Biological description Selective GluK1 kainate receptor antagonist (IC50 = 0.46 µM). Also, positive allosteric GABAA receptor modulator and inhibits carbonic anhydrase (Ki values for rat carbonic anhydrase II and IV are 0.1-1 and 0.2 µM respectively). Inhibits L-type Ca2+ and Nav channels (IC50 = 48.9 µM).Shows anticonvulsant activity.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) and in ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate
Molecular Weight 339.36
Chemical structure Topiramate  [97240-79-4] Chemical Structure
Molecular Formula C12H21NO8S
CAS Number 97240-79-4
PubChem identifier 5284627
SMILES CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C
InChi InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
InChiKey KJADKKWYZYXHBB-XBWDGYHZSA-N
MDL number MFCD00865320

References for Topiramate

References are publications that support the biological activity of the product
  • Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.

    Simeone TA et al (2011) Pharmacol Res 64(1) : 44-52.
  • Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons.

    Gryder DS et al (2003) J Neurosci 23(18) : 7069-74.
  • Topiramate as an inhibitor of carbonic anhydrase isoenzymes.

    Dodgson SJ et al (2000) Epilepsia 41 Suppl 1 : S35-9.
  • Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.

    Zona C et al (1997) Neurosci Lett 231(3) : 123-6.