Product overview
| Name | Topiramate |
| Description | Selective GluK1 kainate receptor antagonist |
| Alternative names | Topamax |
| Purity | >99% |
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Biological Data
| Biological description | Selective GluK1 kainate receptor antagonist (IC50 = 0.46 µM). Also, positive allosteric GABAA receptor modulator and inhibits carbonic anhydrase (Ki values for rat carbonic anhydrase II and IV are 0.1-1 and 0.2 µM respectively). Inhibits L-type Ca2+ and Nav channels (IC50 = 48.9 µM).Shows anticonvulsant activity. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) and in ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate |
| Molecular Weight | 339.36 |
| Chemical structure | ![Topiramate [97240-79-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0618.png "Topiramate [97240-79-4]") |
| Molecular Formula | C12H21NO8S |
| CAS Number | 97240-79-4 |
| PubChem identifier | 5284627 |
| SMILES | CC1(O[C@@H]2CO[C@@]3([C@H]([C@@H]2O1)OC(O3)(C)C)COS(=O)(=O)N)C |
| InChi | InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1 |
| InChiKey | KJADKKWYZYXHBB-XBWDGYHZSA-N |
| MDL number | MFCD00865320 |
References for Topiramate
References are publications that support the biological activity of the product
-
Topiramate modulation of β(1)- and β(3)-homomeric GABA(A) receptors.
Simeone TA et al (2011) Pharmacol Res 64(1) : 44-52. -
Selective antagonism of GluR5 kainate-receptor-mediated synaptic currents by topiramate in rat basolateral amygdala neurons.
Gryder DS et al (2003) J Neurosci 23(18) : 7069-74. -
Topiramate as an inhibitor of carbonic anhydrase isoenzymes.
Dodgson SJ et al (2000) Epilepsia 41 Suppl 1 : S35-9. -
Topiramate attenuates voltage-gated sodium currents in rat cerebellar granule cells.
Zona C et al (1997) Neurosci Lett 231(3) : 123-6.
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