Organoids
Organoids are 3D tissue/organ models made up of pluripotent stem cells and other supporting co-cultured cells eg. epithelial cells. Many types of organoids have been developed to date, including brain, pancreas, heart, lung, intestine, liver, optic cup and cancer organoids. They make stable model systems and can be derived from human stem cells or from patient derived iPSCs. Small molecules are increasingly being used to grow and maintain organoids because of their ease of use and controllable quality, enabling consistent, repeatable results. Researchers can save up to 50% on high purity small molecules used to generate organoids – the range from Hello Bio is around half the price of other suppliers.
10Z-Hymenialdisine (HB1264)
Description:Pan kinase inhibitor. Potently inhibits MEK1, Cdk1, Cdk2, Cdk3 and Cdk5 and GSK-3β.
Purity:>97%
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PD 0325901 (HB2240)
Description:Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.
Purity:>98%
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PD 98059 (HB2244)
Description:Selective MEK1/MAP2K inhibitor. Enhances ESC self-renewal.
Purity:>98%
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Pluripotin (HB2223)
Description:Dual ERK1/RasGAP inhibitor. Maintains ESC self-renewal.
Purity:>98%
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SB 202190 (HB1301)
Description:Potent ATP competitive p38 MAPK inhibitor. 3D growth matrix component, promotes long-term organoid growth and can be used in production of gastric organoids. Promotes stability of human pluripotent stem cells.
Purity:>99%
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SB 203580 (HB1302)
Description:Potent, selective p38 MAPK inhibitor. Stimulates neural stem cell proliferation.
Purity:>98%
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