Product overview

Name PD 98059
Purity >98%
Description Selective MEK1/MAP2K inhibitor. Enhances ESC self-renewal.
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PD 98059: Scientist Approved

Biological Data

Biological description Selective MEK1/MAP2K inhibitor (IC50 values are 2 and 50 µM at MEK1 and MEK2 respectively). Binds to inactivated MEK to prevent its phosphorylation by MEK kinase or c-Raf. Inhibits cell growth and proliferation and induces modest apoptosis. Also enhances embryonic stem cell self-renewal. Active in vivo .

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (25mM) and in ethanol (5mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one
Molecular Weight 267.28
Chemical structure PD 98059 Chemical Structure
Molecular Formula C16H13NO3
CAS Number 167869-21-8
PubChem identifier 4713
InChi InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
MDL number MFCD00671789

References for PD 98059

References are publications that support the biological activity of the product
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
  • U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.

    Hotokezaka H et al (2002) J Biol Chem 277(49) : 47366-72.
  • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.

    Alessi DR et al (1995) J Biol Chem 270(46) : 27489-94.
  • A synthetic inhibitor of the mitogen-activated protein kinase cascade.

    Dudley DT et al (1995) Proc Natl Acad Sci U S A 92(17) : 7686-9.
  • Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor.

    Pang L et al (1995) J Biol Chem 270(23) : 13585-8.

5 Item(s)

These publications cite the use of PD 98059 purchased from Hello Bio:
  • Pre-LTP requires extracellular signal-regulated kinase in the ACC.

    Yamanaka et al (2016) Mol Pain 12 : 1-12
    PubMedID: 27178245

1 Item