Product overview
| Name | PD 98059 |
| Description | Selective MEK1/MAP2K inhibitor. Enhances ESC self-renewal. |
| Purity | >98% |
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Biological Data
| Biological description | Selective MEK1/MAP2K inhibitor (IC50 values are 2 and 50 µM at MEK1 and MEK2 respectively). Binds to inactivated MEK to prevent its phosphorylation by MEK kinase or c-Raf. Inhibits cell growth and proliferation and induces modest apoptosis. Also enhances embryonic stem cell self-renewal. Active in vivo . |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (25mM) and in ethanol (5mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-(2-Amino-3-methoxyphenyl)-4H-1-benzopyran-4-one |
| Molecular Weight | 267.28 |
| Chemical structure |  |
| Molecular Formula | C16H13NO3 |
| CAS Number | 167869-21-8 |
| PubChem identifier | 4713 |
| SMILES | COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2 |
| InChi | InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3 |
| InChiKey | QFWCYNPOPKQOKV-UHFFFAOYSA-N |
| MDL number | MFCD00671789 |
References for PD 98059
References are publications that support the biological activity of the product
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Pre-LTP requires extracellular signal-regulated kinase in the ACC.
Yamanaka et al (2016) Mol Pain 12 : 1-12 -
U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells.
Hotokezaka H et al (2002) J Biol Chem 277(49) : 47366-72. -
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo.
Alessi DR et al (1995) J Biol Chem 270(46) : 27489-94. -
A synthetic inhibitor of the mitogen-activated protein kinase cascade.
Dudley DT et al (1995) Proc Natl Acad Sci U S A 92(17) : 7686-9. -
Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor.
Pang L et al (1995) J Biol Chem 270(23) : 13585-8.
Publications
These publications cite the use of PD 98059 purchased from Hello Bio:
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Pre-LTP requires extracellular signal-regulated kinase in the ACC.
Yamanaka et al (2016) Mol Pain 12 : 1-12PubMedID: 27178245
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