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Images PD 98059: Scientist Approved
PD 98059: Scientist Approved Biological Data Biological description Selective MEK1/MAP2K inhibitor (IC50 values are 2 and 50 µM at MEK1 and MEK2 respectively). Binds to inactivated MEK to prevent its phosphorylation by MEK kinase or c-Raf. Inhibits cell growth and proliferation and induces modest apoptosis. Also enhances embryonic stem cell self-renewal. Active in vivo .
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (25mM) and in ethanol (5mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 2-(2-Amino-3-methoxyphenyl)-4H -1-benzopyran-4-one
Chemical structure
Molecular Formula C16 H13 NO3
SMILES COC1=CC=CC(=C1N)C2=CC(=O)C3=CC=CC=C3O2
InChi InChI=1S/C16H13NO3/c1-19-14-8-4-6-11(16(14)17)15-9-12(18)10-5-2-3-7-13(10)20-15/h2-9H,17H2,1H3
InChiKey QFWCYNPOPKQOKV-UHFFFAOYSA-N
References for PD 98059 References are publications that support the biological activity of the product
Pre-LTP requires extracellular signal-regulated kinase in the ACC. Yamanaka et al (2016) Mol Pain 12 : 1-12 U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264.7 cells into osteoclast-like cells. Hotokezaka H et al (2002) J Biol Chem 277(49) : 47366-72. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. Alessi DR et al (1995) J Biol Chem 270(46) : 27489-94. A synthetic inhibitor of the mitogen-activated protein kinase cascade. Dudley DT et al (1995) Proc Natl Acad Sci U S A 92(17) : 7686-9. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. Pang L et al (1995) J Biol Chem 270(23) : 13585-8.
Publications
These publications cite the use of PD 98059 purchased from Hello Bio:
Pre-LTP requires extracellular signal-regulated kinase in the ACC. Yamanaka et al (2016) Mol Pain 12 : 1-12
Selective MEK1/MAP2K inhibitor. Enhances ESC self-renewal.
Understanding purity and quality - a guide for life scientists
