MTEP hydrochloride is a potent, highly selective and non-competitive mGlu5 receptor antagonist (IC50 = 5 nM and Ki = 16 nM in an in vitro Ca2+-flux assay).
MTEP has no significant effect on other mGluRs and shows fewer off-target effects than MPEP hydrochloride. MTEP shows ~10-fold greater selectivity for mGlu5 than MPEP.
MTEP also blocks induction of tLTP (timing-dependent long term potentiation) and has antidepressant, anxiolytic and neuroprotective properties.
MTEP is active in vivo.
Solubility & Handling
Storage instructions
+4°C (desiccate)
Solubility overview
Soluble in water (100mM) and in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
![MTEP hydrochloride [1186195-60-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0431_2.png "MTEP hydrochloride [1186195-60-7]")
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