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Images Perlapine product vial image | Hello Bio
Perlapine product vial image | Hello Bio Biological Data Biological description Perlapine is a potent agonist at muscarinic based DREADDs such as the excitatory hM3Dq, hM1Dq and inhibitory hM4Di DREADDs (pEC50 values are 8.08, 8.38 and 7.27 at hM3Dq, hM1Dq and hM4Di respectively). Water soluble form also available .
CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 , Salvinorin B (SalB) and perlapine freebase also available.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (50 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 6-(4-Methyl-1-piperazinyl)-11H-dibenz[b,e]azepine
Chemical structure
Molecular Formula C19 H21 N3
SMILES CN1CCN(CC1)C2=NC3=CC=CC=C3CC4=CC=CC=C42
InChi InChI=1S/C19H21N3/c1-21-10-12-22(13-11-21)19-17-8-4-2-6-15(17)14-16-7-3-5-9-18(16)20-19/h2-9H,10-14H2,1H3
InChiKey PWRPUAKXMQAFCJ-UHFFFAOYSA-N
References for Perlapine References are publications that support the biological activity of the product
DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands. Goutaudier et al (2019) eNeuro 6 : (5) DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo Thompson et al (2018) ACS Pharmacol. Transl. Sci. 10.1021 : /acsptsci.8b00012
DREADDs for Neuroscientists. Roth Bl (2016) Neuron 89(4) : 683-94 The first structure-activity relationship studies for designer receptors exclusively activated by designer drugs. Chen et al (2015) ACS Chem Neurosci 6(3) : 476-84 6-(4-Methyl-1-piperazinyl)morphanthridine (Perlapine), a new tricyclic compound with sedative and sleep-promoting properties. A pharmacological study. Stille et al (1973) Psychopharmacologia 24(4) : 325-37
Effective agonist for muscarinic-based DREADDs in vitro and in vivo. Non-CNO chemogenetic actuator
![Perlapine [1977-11-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4889_5.png "Perlapine [1977-11-3]")
Understanding purity and quality - a guide for life scientists
