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Biological Data Biological description Salvinorin B (SALB) is a pharmacologically inert ligand that potently and selectively activates the KORD (the κ-opioid designer receptor (DREADD)) (EC50 = 11.8 nM).
CNO dihydrochloride (water soluble), Clozapine N-oxide (CNO) freebase, Compound 21 Â and perlapine freebase also available.
Please note this item is not for sale in Canada
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in DMSO (20 mM)
Handling
This compound is light sensitive; we therefore recommend protecting the solid and solutions from exposure to light.
Salvinorin B (SalB) is unstable in solution and we recommend that solutions are stored at -20°C and used within 24 hours.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Chemical structure
Molecular Formula C21 H26 O7
PubChem identifier 11440685
SMILES C[C@@]12CC[C@H]3C(=O)O[C@@H](C[C@@]3([C@H]1C(=O)[C@H](C[C@H]2C(=O)OC)O)C)C4=COC=C4
Source Extracted from salvia divinorum
InChi InChI=1S/C21H26O7/c1-20-6-4-12-19(25)28-15(11-5-7-27-10-11)9-21(12,2)17(20)16(23)14(22)8-13(20)18(24)26-3/h5,7,10,12-15,17,22H,4,6,8-9H2,1-3H3/t12-,13-,14-,15-,17-,20-,21-/m0/s1
InChiKey BLTMVAIOAAGYAR-CEFSSPBYSA-N
Appearance Off-white solid
References for Salvinorin B (SALB) References are publications that support the biological activity of the product
DREADDS: Use and application in behavioral neuroscience. Smith et al (206) Behav Neurosci 130(2) : 137-55. DREADDs: The Power of the Lock, the Weakness of the Key. Favoring the Pursuit of Specific Conditions Rather than Specific Ligands. Goutaudier et al (2019) eNeuro 6 : (5) Behavioral and Physiological Effects of a Novel Kappa-Opioid Receptor-Based DREADD in Rats. Marchant et al (2016) Neuropsychopharmacology 41(2) : 402-9. A New DREADD Facilitates the Multiplexed Chemogenetic Interrogation of Behavior. Vardy et al (2015) Neuron. 86(4) : 936-46. Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of kappa-opioid receptor-1 knockout mice. Ansonoff MA et al (2006) J Pharmacol Exp Ther 318 (2): : 641-8.
Publications
These publications cite the use of Salvinorin B (SALB) purchased from Hello Bio:
Somatostatin neurons control an alcohol binge drinking prelimbic microcircuit in mice Dao NC et al (2021) Neuropsychopharmacology 46(11) : 1906-1917 Control of parallel hippocampal output pathways by amygdalar long-range inhibition AlSubaie R et al (2021) Elife 10 mGlu2 and mGlu3 Negative Allosteric Modulators Divergently Enhance Thalamocortical Transmission and Exert Rapid Antidepressant-like Effects Joffe et al. (2020) Neuron 105(1) : 46-59
Potent, selective KORD DREADD activator
![Salvinorin B | [92545-30-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb4887.png "Salvinorin B | [92545-30-7]")
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